Journal: Journal of Bone and Mineral Research

Abbreviation

J Bone Miner Res

Publisher

Oxford University Press

Journal Volumes

ISSN

0884-0431
1523-4681

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2003 - 200962020 - 20253
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Publications 1 - 9 of 9
  • Correlation of 2D trabecular structure parameters with 3D mu CT and measurements of bone strength in femoral bone cores
    Item type: Other Conference Item
    Arnaud, Claude D.; Liew, Seow Wooi; Steines, David; et al. (2003)
    Journal of Bone and Mineral Research
  • Endocannabinoid regulation of bone remodeling
    Item type: Other Conference Item
    Ofek, Itzhak; Fogel, Mark; Attar-Namdar, Malka; et al. (2003)
    Journal of Bone and Mineral Research
  • Micro-computed tomographic analysis of Endosseous titanium implant integration: A novel approach for assessing the anchorage of titanium implants in bone
    Item type: Other Conference Item
    Gabet, Yankel; Kohavi, David; Köhler, Thomas; et al. (2003)
    Journal of Bone and Mineral Research
  • Microfinite Element Modeling Reveals That Transient Deficits In Cortical Bone May Underlie The Adolescent Peak In Forearm Fractures
    Item type: Other Conference Item
    Kirmani, Salrnan; Christen, Dennis; van Lenthe, G. Harry; et al. (2008)
    Journal of Bone and Mineral Research
  • Human parathyroid hormone 1-34 reverses bone loss in orchidectomized adult rats mainly by vastly increasing trabecular thickness
    Item type: Other Conference Item
    Gabet, Yankel; Kohavi, David; Müller, Ralph; et al. (2003)
    Journal of Bone and Mineral Research
  • A new urine assay for sensitive detection and assessment of cancer-induced skeletal perturbations
    Item type: Other Conference Item
    Hillegonds, Darren J.; Burton, Douglas W.; Vogel, John S.; et al. (2007)
    Journal of Bone and Mineral Research
  • Fracture risk prediction in postmenopausal women with traditional and machine learning models in a nationwide, prospective cohort study in Switzerland with validation in the UK Biobank
    Item type: Journal Article
    Lehmann, Oliver; Mineeva, Olga; Veshchezerova, Dinara; et al. (2024)
    Journal of Bone and Mineral Research
    Fracture prediction is essential in managing patients with osteoporosis and is an integral component of many fracture prevention guidelines. We aimed to identify the most relevant clinical fracture risk factors in contemporary populations by training and validating short- and long-term fracture risk prediction models in 2 cohorts. We used traditional and machine learning survival models to predict risks of vertebral, hip, and any fractures on the basis of clinical risk factors, T-scores, and treatment history among participants in a nationwide Swiss Osteoporosis Registry (N = 5944 postmenopausal women, median follow-up of 4.1 yr between January 2015 and October 2022; a total of 1190 fractures during follow-up). The independent validation cohort comprised 5474 postmenopausal women from the UK Biobank with 290 incident fractures during follow-up. Uno’s C-index and the time-dependent area under the receiver operating characteristics curve were calculated to evaluate the performance of different machine learning models (Random survival forest and eXtreme Gradient Boosting). In the independent validation set, the C-index was 0.74 [0.58, 0.86] for vertebral fractures, 0.83 [0.7, 0.94] for hip fractures, and 0.63 [0.58, 0.69] for any fractures at year 2, and these values further increased for longer estimations of up to 7 yr. In comparison, the 10-yr fracture probability calculated with FRAX Switzerland was 0.60 [0.55, 0.64] for major osteoporotic fractures and 0.62 [0.49, 0.74] for hip fractures. The most important variables identified with Shapley additive explanations values were age, T-scores, and prior fractures, while number of falls was an important predictor of hip fractures. Performances of both traditional and machine learning models showed similar C-indices. We conclude that fracture risk can be improved by including the lumbar spine T-score, trabecular bone score, numbers of falls and recent fractures, and treatment information has a significant impact on fracture prediction.
  • Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus
    Item type: Journal Article
    Walle, Matthias; Duseja, Ankita; Whittier, Danielle E.; et al. (2024)
    Journal of Bone and Mineral Research
    Type 1 diabetes mellitus (T1DM) has been linked to increased osteocyte apoptosis, local accumulation of mineralized lacunar spaces, and microdamage suggesting an impairment of the mechanoregulation network in affected individuals. Diabetic neuropathy might exacerbate this dysfunction through direct effects on bone turnover, and indirect effects on balance, muscle strength, and gait. However, the in vivo effects of impaired bone mechanoregulation on bone remodeling in humans remain underexplored. This longitudinal cohort study assessed consenting participants with T1DM and varying degree of distal symmetric sensorimotor polyneuropathy (T1DM, n = 20, median age 46.5 yr, eight female) and controls (CTRL; n = 9, median age 59.0 yr, four female) at baseline and 4–yr follow-up. Nerve conduction in participants with T1DM was tested using DPNCheck and bone remodeling was quantified with longitudinal high–resolution peripheral quantitative–computed tomography (HR-pQCT, 82 μm) at the standard distal sites. Local trabecular bone formation (Tb.F) and resorption (Tb.R) sites were captured by implementing 3D rigid image registration of HR-pQCT images, and the mechanical environment across the bone microarchitecture at these sites was simulated using micro–finite element analysis. We calculated odds ratios to determine the likelihood of bone formation (ORF) and resorption (ORR) with increasing/decreasing strain in percent as markers for mechanoregulation. At the distal radius, Tb.F was 47% lower and Tb.R was 59% lower in T1DM participants compared with CTRL (P < .05). Tb.F correlated positively with nerve conduction amplitude (R = 0.69, P < .05) in participants with T1DM and negatively with glycated hemoglobin (HbA1c) (R = −0.45, P < .05). Additionally, ORF was 34% lower and ORR was 18% lower in T1DM compared with CTRL (P < .05). Our findings represent in vivo evidence suggesting that bone remodeling in individuals with T1DM is in a state of low responsiveness to mechanical stimuli, resulting in impaired bone formation and resorption rates; these correlate to the degree of neuropathy and level of diabetes control.
  • Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture
    Item type: Journal Article
    Whittier, Danielle E.; Walle, Matthias; Atkins, Penny R.; et al. (2025)
    Journal of Bone and Mineral Research
    Distal radius fractures are among the most common fracture sites, with a high incidence across all age groups. High-resolution peripheral quantitative computed tomography (HR-pQCT) has enabled assessment of bone microarchitecture in vivo at the distal radius, providing new insights into the healing process. However, we have observed structural bone loss that is not captured by standard analysis. This study uses void space analysis to quantify the development of localized structural bone loss during fracture healing. Twenty-six participants (21 female, 5 male; aged 18-79 yr) with conservatively-treated distal radius fractures were scanned using HR-pQCT at 6 study visits post-fracture (wk 1, 3, 5, 12, 26, and 52). Total BMD (Tt.BMD), bone volume fraction (BV/TV), and void space volume fraction (VS/TV) were measured. Grip strength relative to the non-fractured wrist and patient rated wrist evaluation (PRWE) were measured at all study visits after cast removal. The cumulative expansion of VS/TV across sequential study visits was quantified to differentiate voids that developed during healing from pre-existing void space. A 5-fold increase in median VS/TV was observed during the follow-up period, from 1.0% (0.6%-9.0%) to 5.5% (2.5%-12.4%). Tt.BMD and BV/TV did not significantly change in this same time interval. Relative grip strength after cast removal was significantly inversely correlated with final VS/TV (ϱ = -0.63, p = .02) and cumulative expansion of new void space during healing (R = -0.67, p <.01), whereas no significant associations were found with age or PRWE. This study suggests that there are adverse changes in bone microarchitecture during fracture healing, despite the preservation of overall Tt.BMD and BV/TV in the same region. Reduced grip strength is correlated with more severe void space formation, but the mechanistic relationship requires further exploration. The formation of void spaces may have long-term implications on bone strength and could provide insight into risk of re-fracture.
Publications 1 - 9 of 9