Journal: Molecular and Cellular Biology
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American Society for Microbiology
32 results
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Publications 1 - 10 of 32
- Regulation of p27 degradation and S-phase progression by Ro52 RING finger proteinItem type: Journal Article
Molecular and Cellular BiologySabile, Abdelmajid; Meyer, Andrea Michael; Wirbelauer, Christiane; et al. (2006) - Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell AngiogenesisItem type: Journal Article
Molecular and Cellular BiologyXie, Zhonglin; Dong, Yunzhou; Zhang, Junhua; et al. (2009) - Interactions of ISW2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templatesItem type: Journal Article
Molecular and Cellular BiologyGelbart, Marnie E.; Rechsteiner, Thomas; Richmond, Timothy J.; et al. (2001) - Kinetochores Prevent Repair of UV Damage in Saccharomyces cerevisiae CentromeresItem type: Journal Article
Molecular and Cellular BiologyCapiaghi, Christoph; Ho, The Vinh; Thoma, Fritz (2004) - Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during GastrulationItem type: Journal Article
Molecular and Cellular BiologyPanic, Linda; Tamarut, Sanda; Sticker-Jantscheff, Melanie; et al. (2006) - The GTPase-activating enzyme Gyp1p is required for recycling of internalized membrane material by inactivation of the Rab/Ypt GTPase Ypt1pItem type: Journal Article
Molecular and Cellular BiologyLafourcade, Céline; Galan, Jean-Marc; Gloor, Yvonne; et al. (2004) - Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor BindingItem type: Journal Article
Molecular and Cellular BiologyKallenberger, Lia; Erb, Rachel; Kralickova, Lucie; et al. (2019) - The NF45/NF90 heterodimer contributes to the biogenesis of 60S ribosomal subunits and influences nucleolar morphologyItem type: Journal Article
Molecular and Cellular BiologyWandrey, F.; Montellese, C.; Koós, K.; et al. (2015) - The HRPT2 tumor suppressor gene product paraifbromin associates with human PAF1 and RNA polymerase IIItem type: Journal Article
Molecular and Cellular BiologyYart, Armelle; Gstaiger, Matthias; Wirbelauer, Christiane; et al. (2005)Inactivation of the HRPT2 tumor suppressor gene is associated with the pathogenesis of the hereditary hyperparathyroidism-jaw tumor syndrome and malignancy in sporadic parathyroid tumors. The cellular function of the HPRT2 gene product, parafibromin, has not been defined yet. Here we show that parafibromin physically interacts with human orthologs of yeast Paf1 complex components, including PAF1, LEO1, and CTR9, that are involved in transcription elongation and 3′ end processing. It also associates with modified forms of the large subunit of RNA polymerase II, in particular those phosphorylated on serine 5 or 2 within the carboxy-terminal domain, that are important for the coordinate recruitment of transcription elongation and RNA processing machineries during the transcription cycle. These interactions depend on a C-terminal domain of parafibromin, which is deleted in ca. 80% of clinically relevant mutations. Finally, RNAi-induced downregulation of parafibromin promotes entry into S phase, implying a role for parafibromin as an inhibitor of cell cycle progression. Taken together, these findings link the tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary parathyroid cancer. - Localization of HET-S to the Cell Periphery, Not to [Het-s] Aggregates, Is Associated with [Het-s]–HET-S ToxicityItem type: Journal Article
Molecular and Cellular BiologyMathur, Vidhu; Seuring, Carolin; Riek, Roland; et al. (2012)
Publications 1 - 10 of 32