Molecular and Cellular Biology

Journal: Molecular and Cellular Biology

Publisher

American Society for Microbiology

ISSN

0270-7306
1098-5549

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Publications 1 - 10 of 32

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
Sabile, Abdelmajid; Meyer, Andrea Michael; Wirbelauer, Christiane; et al. (2006)
Molecular and Cellular Biology
Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis
Xie, Zhonglin; Dong, Yunzhou; Zhang, Junhua; et al. (2009)
Molecular and Cellular Biology
Interactions of ISW2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates
Gelbart, Marnie E.; Rechsteiner, Thomas; Richmond, Timothy J.; et al. (2001)
Molecular and Cellular Biology
Kinetochores Prevent Repair of UV Damage in Saccharomyces cerevisiae Centromeres
Capiaghi, Christoph; Ho, The Vinh; Thoma, Fritz (2004)
Molecular and Cellular Biology
Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation
Panic, Linda; Tamarut, Sanda; Sticker-Jantscheff, Melanie; et al. (2006)
Molecular and Cellular Biology
The GTPase-activating enzyme Gyp1p is required for recycling of internalized membrane material by inactivation of the Rab/Ypt GTPase Ypt1p
Lafourcade, Céline; Galan, Jean-Marc; Gloor, Yvonne; et al. (2004)
Molecular and Cellular Biology
Ectopic Methylation of a Single Persistently Unmethylated CpG in the Promoter of the Vitellogenin Gene Abolishes Its Inducibility by Estrogen through Attenuation of Upstream Stimulating Factor Binding
Kallenberger, Lia; Erb, Rachel; Kralickova, Lucie; et al. (2019)
Molecular and Cellular Biology
The NF45/NF90 heterodimer contributes to the biogenesis of 60S ribosomal subunits and influences nucleolar morphology
Wandrey, F.; Montellese, C.; Koós, K.; et al. (2015)
Molecular and Cellular Biology
The HRPT2 tumor suppressor gene product paraifbromin associates with human PAF1 and RNA polymerase II
Yart, Armelle; Gstaiger, Matthias; Wirbelauer, Christiane; et al. (2005)
Molecular and Cellular Biology
Inactivation of the HRPT2 tumor suppressor gene is associated with the pathogenesis of the hereditary hyperparathyroidism-jaw tumor syndrome and malignancy in sporadic parathyroid tumors. The cellular function of the HPRT2 gene product, parafibromin, has not been defined yet. Here we show that parafibromin physically interacts with human orthologs of yeast Paf1 complex components, including PAF1, LEO1, and CTR9, that are involved in transcription elongation and 3′ end processing. It also associates with modified forms of the large subunit of RNA polymerase II, in particular those phosphorylated on serine 5 or 2 within the carboxy-terminal domain, that are important for the coordinate recruitment of transcription elongation and RNA processing machineries during the transcription cycle. These interactions depend on a C-terminal domain of parafibromin, which is deleted in ca. 80% of clinically relevant mutations. Finally, RNAi-induced downregulation of parafibromin promotes entry into S phase, implying a role for parafibromin as an inhibitor of cell cycle progression. Taken together, these findings link the tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary parathyroid cancer.
Localization of HET-S to the Cell Periphery, Not to [Het-s] Aggregates, Is Associated with [Het-s]–HET-S Toxicity
Mathur, Vidhu; Seuring, Carolin; Riek, Roland; et al. (2012)
Molecular and Cellular Biology

Publications 1 - 10 of 32

Journal: Molecular and Cellular Biology

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