Journal: British journal of Haematology

Abbreviation

Br J Haematol

Publisher

Wiley

Journal Volumes

ISSN

0007-1048
1365-2141

Description

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2021 - 20232
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Publications 1 - 2 of 2
  • Antibody response to a third SARS‐CoV‐2 vaccine dose in recipients of an allogeneic haematopoietic cell transplantation
    Item type: Journal Article
    Bankova, Andriyana K.; Pasin, Chloé; Huang, Alice; et al. (2023)
    British journal of Haematology
    Allogeneic haematopoietic cell transplantation (allo-HCT) recipients show impaired antibody (Ab) response to a standard two-dose vaccination against severe acute respiratory syndrome coronavirus-2 and currently a third dose is recommended as part of the primary vaccination regimen. By assessing Ab titres 1 month after a third mRNA vaccine dose in 74 allo-HCT recipients we show sufficient neutralisation ac-tivity in 77% of the patients. Discontinuation of immunosuppression before the third vaccine led to serological responses in 50% of low responders to two vaccinations. Identifying factors that might contribute to better vaccine responses in allo-HCT recipients is critical to optimise current vaccination strategies.
  • Measurement of long‐term iron absorption and loss during iron supplementation using a stable isotope of iron (57Fe)
    Item type: Journal Article
    Speich, Cornelia; Wegmüller, Rita; Brittenham, Gary M.; et al. (2021)
    British journal of Haematology
    We report the first measurements of long-term iron absorption and loss during iron supplementation in African children using a stable isotope of iron (57Fe). After uniform labelling of body iron with 57Fe, iron absorption is proportional to the rate of decrease in the 57Fe tracer concentration, while iron loss is proportional to the rate of decrease in the 57Fe tracer amount. Anaemic Gambian toddlers were given 2 mg 57Fe orally to equilibrate with total body iron over 8–11 months. After assignment to the positive control arm of the HIGH study, 22 toddlers consumed a micronutrient powder containing 12 mg iron for 12 weeks followed by 12 weeks without iron supplementation. Their daily iron absorption increased 3·8-fold during the iron supplementation period compared to the control period [median (interquartile range, IQR): 1·00 (0·82; 1·28) mg/day vs. 0·26 (0·22; 0·35) mg/day; P = 0·001]. Unexpectedly, during the supplementation period, daily iron loss also increased by 3·4-fold [0·75 (0·55; 0·87) mg/day vs. 0·22 (0·19; 0·29) mg/day; P = 0·005]. Consequently, most (~72%) of the absorbed iron was lost during supplementation. Long-term studies of iron absorption and loss are a promising and accurate method for assessing and quantifying long-term iron balance and may provide a reference method for evaluating iron intervention programs in vulnerable population groups. This study was registered as ISRCTN 0720906. © 2020 British Society for Haematology and John Wiley & Sons Ltd
Publications 1 - 2 of 2