Artificial Organs

Journal: Artificial Organs

Abbreviation

Artif. Organs

Publisher

Wiley-Blackwell

ISSN

1525-1594
0160-564X

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Publications 1 - 10 of 18

Overcoming abnormal joint torque patterns in paretic upper extremities using triceps stimulation
Keller, Thierry; Ellis, Michael D.; Dewald, Julius P. A. (2005)
Artificial Organs
A Soft Total Artificial Heart - First Concept Evaluation on a Hybrid Mock Circulation
Cohrs, Nicholas H.; Petrou, Anastasios; Loepfe, Michael; et al. (2017)
Artificial Organs
Control of the fluid viscosity in a mock circulation
Boës, Stefan; Ochsner, Gregor; Amacher, Raffael; et al. (2018)
Artificial Organs
Standardized comparison of selected physiological controllers for rotary blood pumps: In-vitro study
Petrou, Anastasios; Lee, Jongseok; Dual, Seraina A.; et al. (2018)
Artificial Organs
Computational Simulation of a Non-Newtonian Model of the Blood Separation Process
De Gruttola, Sandro; Boomsma, Kevin; Poulikakos, Dimos (2005)
Artificial Organs
Computational simulation of the blood separation process
De Gruttola, Sandro; Boomsma, Kevin; Poulikakos, Dimos; et al. (2005)
Artificial Organs
Magnetic blood purification-based soluble fms-like tyrosine kinase-1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange
Rduch, Thomas; Arn, Norbert; Kinkel, Janis; et al. (2023)
Artificial Organs
Background Preeclampsia remains one of the most serious complications of pregnancy. Effective therapies are yet to be developed. Recent research has identified an imbalance of angiogenic and antiangiogenic factors as a root cause of preeclampsia. In particular, soluble fms-like tyrosine kinase-1 (sFlt-1) has been shown to bind the angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), reducing blood vessel growth. Increasing preclinical and clinical evidence suggests that removal of the sFlt-1 protein may benefit patients with early onset preeclampsia. sFlt-1 may be removed by conventional blood purification techniques, such as therapeutic plasma exchange (TPE) and dextran sulfate apheresis (DSA), or emerging technologies, including extracorporeal magnetic blood purification (MBP). Methods We compare the performance and selectivity of TPE, DSA, and MBP for the therapeutic removal of sFlt-1. For MPB, we employ magnetic nanoparticles functionalized with either sFlt-1 antibodies or the sFlt-1-binding partner, vascular endothelial growth factor (VEGF). Results We demonstrate that sFlt-1 removal by MBP is feasible and significantly more selective than TPE and DSA at comparable sFlt-1 removal efficiencies (MBP 96%, TPE 92%, DSA 78%). During both TPE and DSA, complement factors (incl. C3c and C4) are depleted to a considerable extent (−90% for TPE, −55% for DSA), while in MBP, complement factor concentrations remain unaltered. We further demonstrate that the removal efficacy of sFlt-1 in the MBP approach is strongly dependent on the nanoparticle type and dose and can be optimized to reach clinically feasible throughputs. Conclusions Taken together, the highly selective removal of sFlt-1 and potential other disease-causing factors by extracorporeal magnetic blood purification may offer new prospects for preeclamptic patients.
Iterative learning control for FES of the ankle
Nguyen, Robert; Micera, Silvestro; Morari, Manfred (2010)
Artificial Organs
Assessment of Finger Forces and Wrist Torques for Functional Grasp Using New Multichannel Textile Neuroprostheses
Lawrence, Marc; Gross, Gion-Pitschen; Lang, Martin; et al. (2008)
Artificial Organs
Display Centre of Pressure Location by Electrotactile Stimulation Using Phantom Sensation
Pfeifer, Serge; Çaldıran, Ozan; Vallery, Heike; et al. (2010)
Artificial Organs

Publications 1 - 10 of 18

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