Journal: Journal of the Mechanical Behavior of Biomedical Materials

Abbreviation

J Mech Behav Biomed Mater

Publisher

Elsevier

Journal Volumes

ISSN

1751-6161
1878-0180

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2012 - 2019442020 - 202632
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Publications 1 - 10 of 76
  • A non-biological model system to simulate the in vivo mechanical behavior of prosthetic meshes
    Item type: Journal Article
    Röhrnbauer, Barbara; Mazza, Edoardo (2013)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Long-term mechanical behaviour of skeletal muscle tissue in semi-confined compression experiments
    Item type: Journal Article
    Böl, Markus B.; Leichsenring, Kay; Ernst, Michael; et al. (2016)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Evaluation of experimental, analytical, and computational methods to determine long-bone bending stiffness
    Item type: Journal Article
    Collins, Caitlyn J.; Yang, Baixuan; Crenshaw, Thomas D.; et al. (2021)
    Journal of the Mechanical Behavior of Biomedical Materials
    Methods used to evaluate bone mechanical properties vary widely depending on the motivation and environment of individual researchers, clinicians, and industries. Further, the innate complexity of bone makes validation of each method difficult. Thus, the purpose of the present research was to quantify methodological error of the most common methods used to predict long-bone bending stiffness, more specifically, flexural rigidity (EI). Functional testing of a bi-material porcine bone surrogate, developed in a previous study, was conducted under four-point bending test conditions. The bone surrogate was imaged using computed tomography (CT) with an isotropic voxel resolution of 0.625 mm. Digital image correlation (DIC) of the bone surrogate was used to quantify the methodological error between experimental, analytical, and computational methods used to calculate EI. These methods include the application of Euler Bernoulli beam theory to mechanical testing and DIC data; the product of the bone surrogate composite bending modulus and second area moment of inertia; and finite element analysis (FEA) using computer-aided design (CAD) and CT-based geometric models. The methodological errors of each method were then compared. The results of this study determined that CAD-based FEA was the most accurate determinant of bone EI, with less than five percent difference in EI to that of the DIC and consistent reproducibility of the measured displacements for each load increment. CT-based FEA was most accurate for axial strains. Analytical calculations overestimated EI and mechanical testing was the least accurate, grossly underestimating flexural rigidity of long-bones.
  • Advanced-Glycation Endproducts: How cross-linking properties affect the collagen fibril behavior
    Item type: Journal Article
    Kamml, Julia; Acevedo, Claire; Kammer, David S. (2023)
    Journal of the Mechanical Behavior of Biomedical Materials
    Advanced-Glycation-Endproducts (AGEs) are known to be a major cause of impaired tissue material properties. In collagen fibrils, which constitute a major building component of human tissue, these AGEs appear as fibrillar cross-links. It has been shown that when AGEs accumulate in collagen fibrils, a process often caused by diabetes and aging, the mechanical properties of the collagen fibril are altered. However, current knowledge about the mechanical properties of different types of AGEs, and their quantity in collagen fibrils is limited owing to the scarcity of available experimental data. Consequently, the precise relationship between the nano-scale cross-link properties, which differ from type to type, their density in collagen fibrils, and the mechanical properties of the collagen fibrils at larger scales remains poorly understood. In our study, we use coarse-grained molecular dynamics simulations and perform destructive tensile tests on collagen fibrils to evaluate the effect of different cross-link densities and their mechanical properties on collagen fibril deformation and fracture behavior. We observe that the collagen fibril stiffens at high strain levels when either the AGEs density or the loading energy capacity of AGEs are increased. Based on our results, we demonstrate that this stiffening is caused by a mechanism that favors energy absorption via stretching rather than inter-molecular sliding. Hence, in these cross-linked collagen fibrils, the absorbed energy is stored rather than dissipated through friction, resulting in brittle fracture upon fibrillar failure. Further, by varying multiple AGEs nano-scale parameters, we show that the AGEs loading energy capacity is, aside from their density in the fibril, the unique factor determining the effect of different types of AGEs on the mechanical behavior of collagen fibrils. Our results show that knowing AGEs properties is crucial for a better understanding of the nano-scale origin of impaired tissue behavior. We further suggest that future experimental investigations should focus on the quantification of the loading energy capacity of AGEs as a key property for their influence on collagen fibrils.
  • Empirical relationships between bone density and ultimate strength: A literature review
    Item type: Review Article
    Fleps, Ingmar; Bahaloo, Hassan; Zysset, Philippe K.; et al. (2020)
    Journal of the Mechanical Behavior of Biomedical Materials
    Introduction Ultimate strength-density relationships for bone have been reported with widely varying results. Reliable bone strength predictions are crucial for many applications that aim to assess bone failure. Bone density and bone morphology have been proposed to explain most of the variance in measured bone strength. If this holds true, it could lead to the derivation of a single ultimate strength-density-morphology relationship for all anatomical sites. Methods All relevant literature was reviewed. Ultimate strength-density relationships derived from mechanical testing of human bone tissue were included. The reported relationships were translated to ultimate strength-apparent density relationships and normalized with respect to strain rate. Results were grouped based on bone tissue type (cancellous or cortical), anatomical site, and loading mode (tension vs. compression). When possible, the relationships were compared to existing ultimate strength-density-morphology relationships. Results Relationships that considered bone density and morphology covered the full spectrum of eight-fold inter-study difference in reported compressive ultimate strength-density relationships for trabecular bone. This was true for studies that tested specimens in different loading direction and tissue from different anatomical sites. Sparse data was found for ultimate strength-density relationships in tension and for cortical bone properties transverse to the main loading axis of the bone. Conclusions Ultimate strength-density-morphology relationships could explain measured strength across anatomical sites and loading directions. We recommend testing of bone specimens in other directions than along the main trabecular alignment and to include bone morphology in studies that investigate bone material properties. The lack of tensile strength data did not allow for drawing conclusions on ultimate strength-density-morphology relationships. Further studies are needed. Ideally, these studies would investigate both tensile and compressive strength-density relationships, including morphology, to close this gap and lead to more accurate evaluation of bone failure.
  • Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model
    Item type: Journal Article
    López, A.; Mestres, G.; Karlsson Ott, M.; et al. (2014)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Cyclic uniaxial compression of human stem cells seeded on a bone biomimetic nanocomposite decreases anti-osteogenic commitment evoked by shear stress
    Item type: Journal Article
    Baumgartner, Walter; Schneider, Isabelle; Hess, Samuel C.; et al. (2018)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Uniaxial and biaxial mechanical characterization of a prosthetic mesh at different length scales
    Item type: Journal Article
    Röhrnbauer, B.; Mazza, Edoardo (2014)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering
    Item type: Journal Article
    Pensalfini, Marco; Ehret, Alexander E.; Stüdeli, Silvia; et al. (2017)
    Journal of the Mechanical Behavior of Biomedical Materials
  • Novel methodology for assessing biomaterial-biofluid interaction in cancellous bone
    Item type: Journal Article
    Bou-Francis, Antony; Soyka, René P. Widmer; Ferguson, Stephen J.; et al. (2015)
    Journal of the Mechanical Behavior of Biomedical Materials
Publications 1 - 10 of 76