Chemistry & Biology

Journal: Chemistry & Biology

Publisher

Cell Press

ISSN

1074-5521
1879-1301

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Publications1 - 10 of 14

Chemoenzymatic synthesis of glycopeptides with PgIB, a bacterial oligosaccharyl transferase from Campylobacter jejuni
Glover, Kerney Jebrell; Weerapana, Eranthie; Numao, Shin; et al. (2005)
Chemistry & Biology
Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers
de Paz, Jose L.; Noti, Christian; Böhm, Friederike; et al. (2007)
Chemistry & Biology
Heparin is a highly sulfated polysaccharide that regulates a variety of cellular processes by interaction with a host of proteins. We report the preparation of synthetic heparin oligosaccharide glycodendrimers and their use as heparin mimetics to regulate heparin-protein interactions. The multivalent display of sugar epitopes mimics the naturally occurring glycans found on cell surfaces and enhances their binding capacity. Binding of the heparin dendrimers to basic fibroblast growth factor (FGF-2) was analyzed using heparin microarray experiments and surface plasmon resonance measurements on gold chips. Heparin-coated dendrimers bind FGF-2 significantly more effectively than monovalent heparin oligosaccharides. Dendrimer 1, which displays multiple copies of the sulfated hexasaccharide (GlcNSO3[6-OSO3]-IdoA[2-OSO3])3, was employed to promote FGF-2-mediated mitogen-activated kinase activation, demonstrating the utility of glycodendrimers to modulate heparin-protein interactions.
Structural Studies of a Peptide with Immune Modulating and Direct Antimicrobial Activity
Wieczorek, Michal; Jenssen, Håvard; Kindrachuk, Jason; et al. (2010)
Chemistry & Biology
Recombination of fragmented proteins
Woycechowsky, Kenneth J. (2004)
Chemistry & Biology
Directed evolution is a powerful method for generating novel molecules with desirable properties. In developing a new sensor to screen for protein-protein interactions, Tafelmeyer et al. [1] report a clever strategy to evolve heterodimeric “split proteins” from a monomer in this issue of Chemistry & Biology.
Metagenomic Approaches for Exploiting Uncultivated Bacteria as a Resource for Novel Biosynthetic Enzymology
Wilson, Micheal C.; Piel, Jörn (2013)
Chemistry & Biology
Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition
Buller, Fabian; Zhang, Yixin; Scheuermann, Jörg; et al. (2009)
Chemistry & Biology
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells
Kinjo, Yuki; Pei, Bo; Bufali, Simone; et al. (2008)
Chemistry & Biology
The Use of Carbohydrate Microarrays to Study Carbohydrate-Cell Interactions and to Detect Pathogens
Disney, Matthew D.; Seeberger, Peter H. (2004)
Chemistry & Biology
Tailor-Made Peptide Synthetases
Kries, Hajo; Hilvert, Donald (2011)
Chemistry & Biology
A subdomain swap strategy for reengineering nonribosomal peptides
Kries, Hajo; Niquille, David L.; Hilvert, Donald (2015)
Chemistry & Biology

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Journal: Chemistry & Biology

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