Journal: Prenatal Diagnosis

Abbreviation

Prenat Diagn

Publisher

Wiley

Journal Volumes

ISSN

0197-3851
1097-0223

Description

Filters

2011 - 201932020 - 20243
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Publications 1 - 6 of 6
  • Cervical softening occurs early in pregnancy: characterization of cervical stiffness in 100 healthy women using the aspiration technique
    Item type: Journal Article
    Badir, S.; Mazza, Edoardo; Zimmermann, R.; et al. (2013)
    Prenatal Diagnosis
  • Factor's that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey
    Item type: Journal Article
    Buchanan, James; Hill, Melissa; Vass, Caroline M.; et al. (2022)
    Prenatal Diagnosis
    Objective We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. Methods Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. Results Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. Conclusion Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.
  • In vivo assessment of the biomechanical properties of the uterine cervix in pregnancy
    Item type: Journal Article
    Mazza, Edoardo; Parra-Saavedra, Miguel; Bajka, Michael; et al. (2014)
    Prenatal Diagnosis
  • Mussel-mimetic tissue adhesive for fetal membrane repair
    Item type: Journal Article
    Haller, C. M.; Bürzle, Wilfried; Brubaker, C. E.; et al. (2011)
    Prenatal Diagnosis
  • Preterm membranes are mechanically more resistant than term membranes
    Item type: Journal Article
    Vergote, Simen; Robmann, Serjosha; Van Der Merwe, Johannes; et al. (2024)
    Prenatal Diagnosis
    ObjectiveTo compare the biomechanical properties of fetal preterm membranes (20 + 0 weeks to 30 + 0 weeks) to those of the term (37 + 0 to 41 + 0 weeks).MethodAmnion and chorion were manually separated and samples were cut to the required geometry. Rectangular samples with (mode 1) and without (uniaxial) a notch, were tested for tearing energy, critical elongation, and tangent stiffness. Suture retention and inter-suture distance testing investigated the effect of suture placement.ResultsFrom the 15 preterm and 10 term placentas studied, no notable differences were observed in uniaxial testing. Mode 1 fracture testing showed a difference in tearing energy between the preterm and term chorion (0.025 +/- 0.005 vs. 0.017 +/- 0.005 J/m-1; p = 0.027) but not in the amnion (0.030 +/- 0.017 vs. 0.029 +/- 0.009 J/m-1; p = 0.895). Both preterm amnion and chorion showed a higher critical elongation compared with term (1.229 +/- 0.057 vs. 1.166 +/- 0.046; p = 0.019 and 1.307 +/- 0.049 vs. 1.218 +/- 0.058; p = 0.012). Preterm amnion had a higher suture retention strength than its term counterpart (0.189 +/- 0.065 vs. 0.121 +/- 0.031 N; p = 0.023). In inter-suture distance tests, no significant interaction was observed beyond 3 mm, but the preterm chorion showed less interaction at 1-2 mm distances.ConclusionPreterm membranes have equivalent or superior tensile properties to term membranes. The chorion appears to contribute to the mechanical integrity of fetal membranes, particularly in preterm stages.
  • Exteriorization of the uterus reduces fetoscopic cannula-induced stress and strain: A finite element model analysis
    Item type: Journal Article
    Ahmad, Mirza A.; Vergote, Simen; Vander Poorten, Emmanuel; et al. (2024)
    Prenatal Diagnosis
    Objective: To estimate stresses and strains in the uterine wall and fetal membranes with single/multi-port fetoscopy, simulating either a percutaneous access or via exteriorized uterus. Study Design: Finite element models based on anatomical dimensions, material properties and boundary conditions were created to simulate stresses, strains and displacements on the uterine wall and fetal membranes during simulated fetal surgery either via exteriorized uterus or percutaneous approach, and with one or three cannulas. Clinically, we measured the anatomical layer thickness and cannula entry point displacement in patients undergoing single port percutaneous fetoscopy. Results: Simulations demonstrate that single port percutaneous fetoscopy increases stress on the fetal membranes (+105%, 128 to 262 kPa) and uterine wall (+115%, 0.89 to 1.9 kPa) compared to exteriorized uterine access. Using three ports increases stress by 110% (148 to 312 kPa) on membranes and 113% (1.08 to 2.3 kPa) on uterine wall. Finite Element Method showed 0.75 cm uterine entry point displacement from the cutaneous entry, while clinical measurements demonstrated displacement of more than double (1.69 ± 0.58 cm), suggesting modeled measurements may be underestimations. Conclusion: The stresses and strains on the fetal membranes and uterus are double as high when entering percutaneously than via an exteriorized uterus. Based on what can be clinically measured, this may be an underestimation.
Publications 1 - 6 of 6