Neurorehabilitation and Neural Repair

Journal: Neurorehabilitation and Neural Repair

Abbreviation

Neurorehabilitation neural repair

Publisher

SAGE

ISSN

1545-9683
0888-4390
1552-6844

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Publications 1 - 10 of 24

Does Subthalamic Deep Brain Stimulation Impact Asymmetry and Dyscoordination of Gait in Parkinson's Disease?
Ravi, Deepak K.; Baumann, Christian R.; Bernasconi, Elena; et al. (2021)
Neurorehabilitation and Neural Repair
Background. Subthalamic deep brain stimulation (STN-DBS) is an effective treatment for selected Parkinson's disease (PD) patients. Gait characteristics are often altered after surgery, but quantitative therapeutic effects are poorly described. Objective. The goal of this study was to systematically investigate modifications in asymmetry and dyscoordination of gait 6 months postoperatively in patients with PD and compare the outcomes with preoperative baseline and to asymptomatic controls without PD. Methods. A convenience sample of thirty-two patients with PD (19 with postural instability and gait disorder (PIGD) type and 13 with tremor dominant disease) and 51 asymptomatic controls participated. Parkinson patients were tested prior to the surgery in both OFF and ON medication states, and 6-months postoperatively in the ON stimulation condition. Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) I to IV and medication were compared to preoperative conditions. Asymmetry ratios, phase coordination index, and walking speed were assessed. Results. MDS-UPDRS I to IV at 6 months improved significantly, and levodopa equivalent daily dosages significantly decreased. STN-DBS increased step time asymmetry (hedges' g effect sizes [95% confidence interval] between pre- and post-surgery: .27 [-.13, .73]) and phase coordination index (.29 [-.08, .67]). These effects were higher in the PIGD subgroup than the tremor dominant (step time asymmetry: .38 [-.06, .90] vs .09 [-.83, 1.0] and phase coordination index: .39 [-.04, .84] vs .13 [-.76, .96]). Conclusions. This study provides objective evidence of how STN-DBS increases asymmetry and dyscoordination of gait in patients with PD and suggests motor subtypes-associated differences in the treatment response.
Spinal Reflex Activity
Hubli, Michèle; Dietz, Volker; Bolliger, Marc (2012)
Neurorehabilitation and Neural Repair
Combined Analysis of Cortical (EEG) and Nerve Stump Signals Improves Robotic Hand Control
Tombini, Mario; Rigosa, Jacopo; Zappasodi, Filippo; et al. (2012)
Neurorehabilitation and Neural Repair
Movement Observation Activates Lower Limb Motor Networks in Chronic Complete Paraplegia
Hotz-Boendermaker, Sabina; Hepp-Reymond, Marie-Claude; Curt, Armin; et al. (2011)
Neurorehabilitation and Neural Repair
Reliability and Responsiveness of Upper Limb Motor Assessments for Children with Central Neuromotor Disorders: A Systematic Review
Gerber, Corinna N.; Labruyere, Rob; van Hedel, Hubertus J.A. (2016)
Neurorehabilitation and Neural Repair
Beneficial "Pharmaceutical Pleiotropy" of Gabapentinoids in Spinal Cord Injury: A Case for Refining Standard-of-Care
Cragg, Jacquelyn J.; Jutzeler, Catherine; Grassner, Lukas; et al. (2020)
Neurorehabilitation and Neural Repair
Spinal cord injury results in devastating neurological deficits accompanied by lifelong disability and significant economic burden. While the development of novel compounds or cell-based interventions for spinal cord injury is unquestionably worthwhile, a complementary approach examines current standards of care and the degree to which these can be optimized to benefit long-term neurological function. Numerous classes of drugs, already in use in the acute phase of spinal cord injury, are intriguing because they (1) readily cross the blood-spinal cord barrier to modulate activity in the central nervous system and (2) are administered during a window of time in which neuroprotection, and even some repair, are feasible. Here, we review a rare case of convergent lines of evidence from both preclinical and human studies to support the early administration of a class of drug (ie, gabapentinoids) to both foster motor recovery and reduce the severity of neuropathic pain.
Falls in persons with spinal cord injury
Wirz, Markus; Müller, Roland; Bastiaenen, Caroline (2010)
Neurorehabilitation and Neural Repair
High-Impact, Self-Motivated Training Within an Enriched Environment With Single Animal Tracking Dose-Dependently Promotes Motor Skill Acquisition and Functional Recovery
Starkey, Michelle L.; Bleul, Christiane; Kasper, Hansjörg; et al. (2014)
Neurorehabilitation and Neural Repair
Real-World Functional Grasping Activity in Individuals With Stroke and Healthy Controls Using a Novel Wearable Wrist Sensor
Yang, Chieh-ling; Liu, Johnson; Simpson, Lisa A.; et al. (2021)
Neurorehabilitation and Neural Repair
Method to Reduce Muscle Fatigue during Transcutaneous Neuromuscular Electrical Stimulation in Major Knee and Ankle Muscle Groups
Sayenko, Dimitry G.; Nguyen, Robert; Hirabayashi, Tomoyo; et al. (2015)
Neurorehabilitation and Neural Repair

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Journal: Neurorehabilitation and Neural Repair

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