Journal: Osteoporosis International

Abbreviation

Osteoporos Int

Publisher

Springer

Journal Volumes

ISSN

0937-941X
1433-2965
0936-6555

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Publications1 - 10 of 50
  • Does thoracic or lumbar spine bone architecture predict vertebral failure strength more accurately than density?
    Item type: Journal Article
    Lochmüller, E.-M.; Pöschl, K.; Würstlin, L.; et al. (2008)
    Osteoporosis International
  • Influence of osteoporosis on fracture fixation - a systematic literature review
    Item type: Journal Article
    Goldhahn, Jörg; Suhm, Norbert; Goldhahn, Sabine; et al. (2008)
    Osteoporosis International
  • The 5-Year Risk for Contralateral Hip Fracture after the First One - A Simple Algorithm for Risk Stratification
    Item type: Journal Article
    Goldhahn, Jörg; Vestergaard, P.; Bachmann, L.M. (2012)
    Osteoporosis International
  • Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study
    Item type: Journal Article
    Praveen, Anitha D.; Aspelund, Thor; Ferguson, Stephen J.; et al. (2024)
    Osteoporosis International
    Summary: There is imminent refracture risk in elderly individuals for up to six years, with a decline thereafter except in women below 75 who face a constant elevated risk. Elderly men with fractures face the highest mortality risk, particularly those with hip and vertebral fractures. Targeted monitoring and treatment strategies are recommended. Purpose: Current management and interventions for osteoporotic fractures typically focus on bone mineral density loss, resulting in suboptimal evaluation of fracture risk. The aim of the study is to understand the progression of fractures to refractures and mortality in the elderly using multi-state models to better target those at risk. Methods: This prospective, observational study analysed data from the AGES-Reykjavik cohort of Icelandic elderly, using multi-state models to analyse the evolution of fractures into refractures and mortality, and to estimate the probability of future events in subjects based on prognostic factors. Results: At baseline, 4778 older individuals aged 65 years and older were included. Elderly men, and elderly women above 80 years of age, had a distinct imminent refracture risk that lasted between 2–6 years, followed by a sharp decline. However, elderly women below 75 continued to maintain a nearly constant refracture risk profile for ten years. Hip (30–63%) and vertebral (24–55%) fractures carried the highest 5-year mortality burden for elderly men and women, regardless of age, and for elderly men over 80, lower leg fractures also posed a significant mortality risk. Conclusion: The risk of refracture significantly increases in the first six years following the initial fracture. Elderly women, who experience fractures at a younger age, should be closely monitored to address their long-term elevated refracture risk. Elderly men, especially those with hip and vertebral fractures, face substantial mortality risk and require prioritized monitoring and treatment.
  • Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures
    Item type: Review Article
    Boonen, S.; Wahl, D.A.; Nauroy, L.; et al. (2011)
    Osteoporosis International
  • NONINVASIVE EVALUATION OF BONE STRENGTH
    Item type: Conference Paper
    Mueller, R. (2011)
    Osteoporosis International
  • Advances in bone architectural imaging techniques
    Item type: Other Conference Item
    Müller, Ralph (2007)
    Osteoporosis International
  • The rise and fall of raloxifene use for osteoporosis, 1999-2022
    Item type: Journal Article
    Shogry, Freddy F.; Hayes, Kaleen N.; Kim, Sandra; et al. (2025)
    Osteoporosis International
    Summary The relevance of raloxifene in current osteoporosis practice is not clear given concerns about its safety and the introduction of newer therapeutic options. We describe the rise and fall in raloxifene use among older females in Ontario, documenting that it remains an important therapeutic option for osteoporosis in select patients. Purpose Raloxifene has been available in Canada for postmenopausal osteoporosis since 1998. However, its benefit-to-risk ratio became questioned after evidence of increased risk of thrombosis and fatal stroke emerged in the early 2000s. We aimed to describe the use of raloxifene over time. Methods We identified community-dwelling females aged ≥ 66 years initiating raloxifene between 1999/05 and 2022/12 through the Ontario Drug Benefit program, plotted the number of incident and prevalent users by calendar year, and estimated persistence with therapy using a 60-day permissible gap. Patient characteristics were described using medical and pharmacy claims within the year prior to initiation. Results We identified 21,896 eligible females (mean age = 74.2 [SD = 6.2] years, 5% fracture history, 57% oral bisphosphonate history). The number of patients initiating raloxifene increased to an annual high of 3,824 in 2001 followed by a 15% drop in 2002 (n = 3,252) before a gradual decline from 2,113 in 2003 to 90 in 2022. In contrast, the number of prevalent users remained >5,000 annually between 2003 and 2011, with a gradual drop from 4,670 in 2012 to 959 in 2022. Overall, 29% persisted with therapy for ≥ 3 years. Besides known population-level treatment trends (increased statins, decreased estrogen therapy), little differences in patient characteristics were identified over time. Conclusion Raloxifene initiation has declined substantially since 2003, and overall utilization has declined rapidly since 2012. While less than 100 initiators were identified annually in recent years, around 1,000 continue to take raloxifene every year. Raloxifene thus remains a relevant option among select patients with osteoporosis.
  • Relationship between microarchitecture and bone strength
    Item type: Conference Paper
    Müller, Ralph (2007)
    Osteoporosis International
  • Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy
    Item type: Journal Article
    Cohen, Adi; Dempster, David W.; Müller, Ralph; et al. (2010)
    Osteoporosis International
    Summary We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the “gold standard,” transiliac bone biopsy. Methods HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39 ± 10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (µCT). Apparent Young’s modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (µFE) of biopsy µCT and HR-pQCT images. Results The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by µCT of biopsies and HR-pQCT of the radius (R 0.365–0.522; P < 0.01). Cortical width of biopsies correlated with cortical thickness by HR-pQCT, but only at the tibia (R = 0.360, P < 0.01). Apparent Young’s modulus calculated by µFE of biopsies correlated with that calculated for both radius (R = 0.442; P < 0.001) and tibia (R = 0.380; P < 0.001) HR-pQCT scans. Conclusions The associations between peripheral (HR-pQCT) and axial (transiliac biopsy) measures of microarchitecture and estimated mechanical competence are significant but modest.
Publications1 - 10 of 50