Journal: Nature Reviews Endocrinology

Abbreviation

Nat Rev Endocrinol

Publisher

Nature

Journal Volumes

ISSN

1759-5037
1759-5029

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2010 - 201952020 - 20263
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Publications 1 - 8 of 8
  • Challenges and opportunities of wearable molecular sensors in endocrinology and metabolism
    Item type: Journal Article
    Güntner, Andreas T.; Gerber, Philipp A.; Dittrich, Petra S.; et al. (2026)
    Nature Reviews Endocrinology
    Wearable technologies that analyse non-conventional biological matrices, such as interstitial fluid, sweat, tears or breath, have the potential to provide longitudinal biomarker data with minimal invasiveness. These data could provide insights into physiological and behavioural patterns, in particular outside medical care facilities. Despite the success of continuous glucose monitoring, the adoption of wearable sensors for managing endocrine and metabolic diseases remains limited. This Perspective highlights five key challenges and proposes solutions. First, understanding the physiology of longitudinal biomarker profiles is crucial for uncovering rhythmic patterns and physiological interrelations in the prediction of health trajectories. Second, technical barriers currently hinder the continuous monitoring of most clinically relevant biomarkers. Third, machine learning models often struggle with the complexity of dense biomarker datasets, which increases the risk of spurious correlations. Fourth, the diagnostic value of wearable sensor data requires validation through clinical studies, and predicting treatment outcomes necessitates diverse and large patient cohorts over extended observation periods in real-world settings. Finally, most wearable devices function as isolated solutions. Thus, they lack interoperability and integration into clinical pathways, and often fail to incorporate context and user input. Addressing these challenges will be key for advancing the role of wearable sensors in endocrine and metabolic care in future health-care settings.
  • NUTRITION: Are mild maternal iodine deficiency and child IQ linked?
    Item type: Other Journal Item
    Zimmermann, Michael B. (2013)
    Nature Reviews Endocrinology
  • Animal models of obesity and diabetes mellitus
    Item type: Review Article
    Kleinert, Maximilian; Clemmensen, Christoffer; Hofmann, Susanna M.; et al. (2018)
    Nature Reviews Endocrinology
  • Functional diversity of human adipose tissue revealed by spatial mapping
    Item type: Other Journal Item
    Scheele, Camilla; Wolfrum, Christian (2021)
    Nature Reviews Endocrinology
    By mapping the spatial organization of adipose tissue, Bäckdahl and colleagues identify adipocyte progenitor structures as well as three subclasses of adipocytes with different molecular functions, including insulin sensitivity and leptin signalling.
  • The metabolic actions of glucagon revisited
    Item type: Review Article
    Habegger, Kirk M.; Heppner, Kristy M.; Geary, Nori; et al. (2010)
    Nature Reviews Endocrinology
    The initial identification of glucagon as a counter-regulatory hormone to insulin revealed this hormone to be of largely singular physiological and pharmacological purpose. Glucagon agonism, however, has also been shown to exert effects on lipid metabolism, energy balance, body adipose tissue mass and food intake. The ability of glucagon to stimulate energy expenditure, along with its hypolipidemic and satiating effects, in particular, make this hormone an attractive pharmaceutical agent for the treatment of dyslipidemia and obesity. Studies that describe novel preclinical applications of glucagon, alone and in concert with glucagon-like peptide 1 agonism, have revealed potential benefits of glucagon agonism in the treatment of the metabolic syndrome. Collectively, these observations challenge us to thoroughly investigate the physiology and therapeutic potential of insulin's long-known opponent.
  • Intricacies and obscurities of non-shivering thermogenesis
    Item type: Other Journal Item
    Sharma, Anand Kumar (2025)
    Nature Reviews Endocrinology
  • Salt iodization halves risk of thyrotoxicosis in Denmark
    Item type: Other Journal Item
    Zimmermann, Michael B. (2019)
    Nature Reviews Endocrinology
  • Iodine deficiency and thyroid nodules
    Item type: Other Journal Item
    Zimmermann, Michael B. (2014)
    Nature Reviews Endocrinology
    Availability of longitudinal data on the evolution of thyroid nodules and how this progression is influenced by changes in iodine intake is limited. A systematic 11-year follow-up study in Danish adults offers new insights into the relationships between thyroid nodularity, age and iodine intake.
Publications 1 - 8 of 8