The Journal of Thoracic and Cardiovascular Surgery

Journal: The Journal of Thoracic and Cardiovascular Surgery

Abbreviation

J Thorac Cardiovasc Surg

Publisher

Mosby

ISSN

0022-5223
1097-685X

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Publications 1 - 8 of 8

Three-dimensional template-based planning for transapical aortic valve implantation
Jacobs, Stephan; Gessat, Michael; Walther, Thomas; et al. (2011)
The Journal of Thoracic and Cardiovascular Surgery
Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury
Aregger, Fabienne; Pilop, Christiane; Uehlinger, Dominik E.; et al. (2010)
The Journal of Thoracic and Cardiovascular Surgery
Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma
Lardinois, D.; Jung, F.J.; Opitz, I.; et al. (2006)
The Journal of Thoracic and Cardiovascular Surgery
Virtual surgical planning, flow simulation and 3D electro-spinning of patient-specific grafts to optimize Fontan hemodynamics
Siallagan, Dominik; Loke, Yue-Hin; Olivieri, Laura; et al. (2018)
The Journal of Thoracic and Cardiovascular Surgery
Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
Walpoth, Beat H.; Zammaretti, Prisca; Cikirikcioglu, Mustafa; et al. (2007)
The Journal of Thoracic and Cardiovascular Surgery
Objective Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency. Methods Pigs underwent bilateral carotid artery interposition of expanded polytetrafluoroethylene grafts either impregnated with fibrin (n = 11)—engineered to locally release vascular endothelial growth factor121 (vascular endothelial growth factor–fibrin; n = 11)—or left uncoated (n = 12). Graft patency was assessed by quantitative carotid angiography followed by graft histomorphometry at the 1-month experimental end point. Results Patency rates were not significantly different between study groups. Grafts coated with fibrin or vascular endothelial growth factor–fibrin exhibited significantly increased angiographic narrowing at the proximal anastomosis (for both P < .05 vs uncoated) and no difference at the distal anastomosis and the grafts’ middle. Histological analysis showed 80% to 90% endothelial coverage and buildup of intima throughout the lengths of all grafts. Examination of the grafts’ midportion revealed significantly enlarged neointimal layers of smooth muscle actin-positive cells in grafts coated with vascular endothelial growth factor–fibrin (242 ± 47 μm2/μ) and fibrin (177 ± 41 μm2/μ), compared with uncoated grafts (131 ± 39 μm2/μ) (for both P < .05 vs uncoated). This thickening could not be explained by enhanced inflammation or vessel wall angiogenesis, which were minimal at the experimental end point. Conclusions Fibrin and vascular endothelial growth factor produced effects deleterious to graft healing, by increasing the narrowing at proximal anastomosis and neointimal growth beyond that seen in uncoated grafts. It may reflect direct activation by exogenous vascular endothelial growth factor of vascular smooth muscle cells.
Long-term follow-up, computed tomography, and computational fluid dynamics of the Cabrol procedure
Knight, Joseph; Baumüller, Stephan; Kurtcuoglu, Vartan; et al. (2010)
The Journal of Thoracic and Cardiovascular Surgery
Control of ventricular unloading using an electrocardiogram-synchronized Thoratec paracorporeal ventricular assist device
Amacher, R.; Weber, A.; Brinks, H.; et al. (2013)
The Journal of Thoracic and Cardiovascular Surgery
Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass
Grünenfelder, Jürg; Umbehr, Martin; Plass, Andre; et al. (2004)
The Journal of Thoracic and Cardiovascular Surgery

Publications 1 - 8 of 8

Journal: The Journal of Thoracic and Cardiovascular Surgery

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