Journal: Angewandte Chemie. International Edition

Abbreviation

Angew. Chem. Int. Ed.

Publisher

Wiley-VCH

Journal Volumes

ISSN

1433-7851
1521-3773
0570-0833

Description

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Publications 1 - 10 of 957
  • Carrier‐Induced Modification of Palladium Nanoparticles on Porous Boron Nitride for Alkyne Semi‐Hydrogenation
    Item type: Journal Article
    Büchele, Simon; Chen, Zupeng; Fako, Edvin; et al. (2020)
    Angewandte Chemie. International Edition
    Chemical modifiers enhance the efficiency of metal catalysts in numerous applications, but their introduction often involves toxic or expensive precursors and complicates the synthesis. Here, we show that a porous boron nitride carrier can directly modify supported palladium nanoparticles, originating unparalleled performance in the continuous semi‐hydrogenation of alkynes. Analysis of the impact of various structural parameters reveals that using a defective high surface area boron nitride and ensuring a palladium particle size of 4–5 nm is critical for maximizing the specific rate. The combined experimental and theoretical analyses point towards boron incorporation from defects in the support to the palladium subsurface, creating the desired isolated ensembles determining the selectivity. This practical approach highlights the unexplored potential of using tailored carriers for catalyst design. © 2020 Wiley‐VCH GmbH.
  • Prebiotic Peptide Synthesis and Spontaneous Amyloid Formation Inside a Proto‐Cellular Compartment
    Item type: Journal Article
    Kwiatkowski, Witek; Bomba, Radoslaw; Afanasyev, Pavel; et al. (2021)
    Angewandte Chemie. International Edition
    Cellular life requires a high degree of molecular complexity and self‐organization, some of which must have originated in a prebiotic context. Here, we demonstrate how both of these features can emerge in a plausibly prebiotic system. We found that chemical gradients in simple mixtures of activated amino acids and fatty acids can lead to the formation of amyloid‐like peptide fibrils that are localized inside of a proto‐cellular compartment. In this process, the fatty acid or lipid vesicles act both as a filter, allowing the selective passage of activated amino acids, and as a barrier, blocking the diffusion of the amyloidogenic peptides that form spontaneously inside the vesicles. This synergy between two distinct building blocks of life induces a significant increase in molecular complexity and spatial order thereby providing a route for the early molecular evolution that could give rise to a living cell. © 2020 Wiley‐VCH GmbH.
  • Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance
    Item type: Journal Article
    Nguyen, Dzung; Abdullin, Dinar; Heubach, Caspar A.; et al. (2021)
    Angewandte Chemie. International Edition
    Mechanistic insights into protein-ligand interactions can yield chemical tools for modulating protein function and enable their use for therapeutic purposes. For the homodimeric enzyme tRNA-guanine transglycosylase (TGT), a putative virulence target of shigellosis, ligand binding has been shown by crystallography to transform the functional dimer geometry into an incompetent twisted one. However, crystallographic observation of both end states does neither verify the ligand-induced transformation of one dimer into the other in solution nor does it shed light on the underlying transformation mechanism. We addressed these questions in an approach that combines site-directed spin labeling (SDSL) with distance measurements based on pulsed electron-electron double resonance (PELDOR or DEER) spectroscopy. We observed an equilibrium between the functional and twisted dimer that depends on the type of ligand, with a pyranose-substituted ligand being the most potent one in shifting the equilibrium toward the twisted dimer. Our experiments suggest a dissociation-association mechanism for the formation of the twisted dimer upon ligand binding.
  • Amyloid-Templated Palladium Nanoparticles for Water Purification by Electroreduction
    Item type: Journal Article
    Teng, Jie; Peydayesh, Mohammad; Lu, Jiandong; et al. (2022)
    Angewandte Chemie. International Edition
    Electrocatalysis offers great promise for water purification but is limited by low active area and high uncontrollability of electrocatalysts. To overcome these constraints, we propose hybrid bulk electrodes by synthesizing and binding a Pd nanocatalyst (nano-Pd) to the electrodes via amyloid fibrils (AFs). The AFs template is effective for controlling the nucleation, growth, and assembly of nano-Pd on the electrode. In addition, the three-dimensional hierarchically porous nanostructure of AFs is beneficial for loading high-density nano-Pd with a large active area. The novel hybrid cathodes exhibit superior electroreduction performance for the detoxification of hexavalent chromium (Cr6+), 4-chlorophenol, and trichloroacetic acid in wastewater and drinking water. This study provides a proof-of-concept design of an AFs-templated nano-Pd-based hybrid electrode, which constitutes a paradigm shift in electrocatalytic water purification, and broadens the horizon of its potential engineered applications.
  • One- and Two-Dimensional NMR Spectroscopy with a Magnetic-Resonance Force Microscope
    Item type: Journal Article
    Eberhardt, Kai W.; Degen, Christian L.; Hunkeler, Andreas; et al. (2008)
    Angewandte Chemie. International Edition
  • Teruaki Mukaiyama (1927-2018)
    Item type: Other Journal Item
    Seebach, Dieter (2019)
    Angewandte Chemie. International Edition
  • Automated De Novo Drug Design: Are We Nearly There Yet?
    Item type: Review Article
    Schneider, Gisbert; Clarke, David E. (2019)
    Angewandte Chemie. International Edition
  • Bimetallic Aerogels: High-Performance Electrocatalysts for the Oxygen Reduction Reaction
    Item type: Journal Article
    Liu, W.; Rodriguez, P.; Borchardt, L.; et al. (2013)
    Angewandte Chemie. International Edition
  • Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction
    Item type: Journal Article
    Garrabou, Xavier; Macdonald, Duncan Stuart; Wicky, Basile I.M.; et al. (2018)
    Angewandte Chemie. International Edition
  • Combining Structure Modeling and Electron Microscopy to Determine Complex Zeolite Framework Structures
    Item type: Journal Article
    Li, Yi; Yu, Jihong; Xu, Ruren; et al. (2008)
    Angewandte Chemie. International Edition
Publications 1 - 10 of 957