Journal: Advanced Materials

Abbreviation

Adv Mater

Publisher

Wiley-VCH

Journal Volumes

ISSN

0935-9648
1521-4095

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Publications 1 - 10 of 269
  • Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
    Item type: Journal Article
    Fenton, Owen S.; Kauffman, Kevin J.; McClellan, Rebecca L.; et al. (2016)
    Advanced Materials
  • Efficient, Stable Bulk Charge Transport in Crystalline/Crystalline Semiconductor–Insulator Blends
    Item type: Journal Article
    Kumar, Avinesh; Baklar, Mohammed A.; Scott, Ken; et al. (2009)
    Advanced Materials
  • Recent Advances in Wearable Transdermal Delivery Systems
    Item type: Review Article
    Amjadi, Morteza; Sheykhansari, Sahar; Nelson, Bradley J.; et al. (2018)
    Advanced Materials
  • 3D Motion Manipulation for Micro- and Nanomachines: Progress and Future Directions
    Item type: Review Article
    Huang, Hai; Yang, Shihao; Ying, Yulong; et al. (2024)
    Advanced Materials
    In the past decade, micro- and nanomachines (MNMs) have made outstanding achievements in the fields of targeted drug delivery, tumor therapy, microsurgery, biological detection, and environmental monitoring and remediation. Researchers have made significant efforts to accelerate the rapid development of MNMs capable of moving through fluids by means of different energy sources (chemical reactions, ultrasound, light, electricity, magnetism, heat, or their combinations). However, the motion of MNMs is primarily investigated in confined two-dimensional (2D) horizontal setups. Furthermore, three-dimensional (3D) motion control remains challenging, especially for vertical movement and control, significantly limiting its potential applications in cargo transportation, environmental remediation, and biotherapy. Hence, an urgent need is to develop MNMs that can overcome self-gravity and controllably move in 3D spaces. This review delves into the latest progress made in MNMs with 3D motion capabilities under different manipulation approaches, discusses the underlying motion mechanisms, explores potential design concepts inspired by nature for controllable 3D motion in MNMs, and presents the available 3D observation and tracking systems.
  • Amyloid-Templated Ceria Nanozyme Reinforced Microneedle for Diabetic Wound Treatments
    Item type: Journal Article
    Xuan, Qize; Cai, Jiazhe; Gao, Yuan; et al. (2025)
    Advanced Materials
    Amyloid fibrils have emerged as excellent templates and building blocks for the development of ordered functional materials with considerable potential in biomedical applications. Here, lysozyme amyloid fibrils (Lys-AFs) are employed as templates for the in situ synthesis of ceria nanozymes (Lys-AFs-Ceria) with ultrafine dimensions, an optimized Ce³⁺/Ce⁴⁺ ratio, and uniform distribution on the fibril surface, addressing the challenges of low catalytic efficiency and high susceptibility to aggregation typical of traditional methods. As a proof of concept, it is further applied Lys-AFs-Ceria to develop hydrogel/microneedle for treating bacteria-infected diabetic wounds via non-covalent interactions between polyphenols and amyloid fibrils incorporating glucose oxidase (GOX). The hydrogel/microneedle facilitates superoxide dismutase and catalase cascade catalysis by Lys-AFs-Ceria, and integrates GOX-mediated glucose consumption, synergistically achieving glucose reduction, reactive oxygen species elimination, and hypoxia alleviation in the diabetic wound infection microenvironment. In addition to antibacterial properties and tissue regeneration promotion of Lys-AFs scaffold, Lys-AFs-Ceria regulates macrophages polarization toward an anti-inflammatory M2 state. Collectively, these attributes contribute to the enhanced efficacy of diabetic wound healing, with in vivo studies demonstrating increased healing efficiency following a single application, and more in general an effective strategy toward high-catalytic and stable nanozymes.
  • Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
    Item type: Journal Article
    Rahimi, Ehsan; Palacios-Corella, Mario; Mol, Arjan; et al. (2025)
    Advanced Materials
    Kelvin probe force microscopy (KPFM) is a highly advanced technique offering notable surface sensitivity and high lateral resolution, ranging from micrometres to the sub-nanometre scale. This scanning probe technique effectively detects local electrical surface potential (ESP), influenced charge distribution, and work function differences, making it essential for studying biological and biochemical processes, from single molecules to complex cellular structures. By enabling nanometre-resolution analysis under simulated conditions, KPFM provides crucial insights into the physicochemical evolution, functionality, and structural organization of biomolecular systems. Recent advancements have significantly expanded KPFM’s capabilities, revealing ESP characteristics in diverse biological entities, including single proteins, DNA strands, lipid films, fibrils, and complex neuronal structures. The technique also facilitates the study of biomolecular nanolayers on advanced nanomaterials like gold nanoparticles and carbon nanotubes, enhancing its role in bio-nanotechnology. Such versatility highlights KPFM’s transformative potential in elucidating biomolecular interactions at unprecedented resolutions. This review critically analyses recent advancements, addresses ongoing challenges in measuring ESP in biological samples, and highlights emerging strategies to improve resolution and sensitivity. Additionally, KPFM’s implications in diagnostics, biosensing, tissue engineering, therapeutics, drug screening, and Alzheimer’s research are explored, establishing it as a powerful tool at the intersection of nanotechnology and biomedical innovation.
  • Upconversion Nanoparticle-Covalent Organic Framework Core-shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging
    Item type: Journal Article
    Kim, Dong Wook; Wrede, Paul; Rodríguez-Camargo, Andrés; et al. (2025)
    Advanced Materials
    Despite the development of various medical imaging contrast agents, integrating contrast signal generation with therapeutic and microrobotic functions remains challenging without complicated fabrication processes. In this study, upconversion nanoparticle-covalent organic framework (UCNP-COF) core-shell sub-micron particles are developed that function as therapeutic microrobots trackable with multi-spectral optoacoustic tomography (MSOT) imaging and can be loaded with desired therapeutic molecular agents in a customizable manner. The mechanism of optoacoustic signal generation in UCNP-COF particles is attributed to the quenching of upconversion luminescence emitted by the UCNPs, which is absorbed by the encapsulating COF and subsequently converted into acoustic waves. Unlike other microparticulate agents previously imaged with MSOT, UCNP-COF particles do not pose concerns about their stability and biocompatibility. Simultaneously, the mesoporous texture of the COF provides a large surface area, allowing for the efficient loading of various drug molecules, which can be released at target sites. Furthermore, the magnetic UCNP-COF Janus particles can be magnetically navigated through in vivo vasculature while being visualized in real-time with volumetric MSOT. This study proposes an approach to design photonic materials with multifunctionality, enabling high-performance medical imaging, drug delivery, and microrobotic manipulation toward their future potential clinical use.
  • Biocompatible Ink Optimization Enables Functional Volumetric Bioprinting With Xolography
    Item type: Journal Article
    Brauer, Erik; Balciunaite, Aiste; Kollert, Matthias R.; et al. (2025)
    Advanced Materials
    Xolography is a novel linear volumetric manufacturing technique that offers unparalleled precision and speed. Yet, its application to bioprinting remains limited due to insufficient understanding of biocompatibility constraints. Here, this work establishes fundamental design principles for cell-compatible Xolography bioinks by dissecting the effects of extracellular pH, osmolality, and lysosomotropic stress on cell viability and function. By systematically studying the tolerances for these parameters, this work defines a framework for bioink formulations that enables fast, support-free fabrication of complex designs with maintained cell viability and function as validated in different murine and human cell lines, primary human cells and induced pluripotent stem cell (iPSC)-derived cells. These results show that, unlike triethanolamine, BisTris indeed can function as a fully biocompatible co-initiator enabling cell viability beyond 90% as well as uncompromised metabolic activity and differentiation performance when used in a tightly controlled formulation, contrasting previous reports. This work showcases the biomedical potential of the formulation by achieving fibroblast-driven extracellular matrix (ECM) formation, endothelial sprouting from pre-vascularized spheroids, and maintenance of an iPSC-derived hepatocyte differentiation phenotype within Xolography-printed constructs. These advancements transform Xolography into a powerful and foremost reliable bioprinting platform for fabrication of complex, cell-laden structures for versatile applications in tissue engineering, organ-on-a-chip models, and regenerative medicine.
  • Micropatterning Layers by Flame Aerosol Deposition-Annealing
    Item type: Journal Article
    Tricoli, Antonio; Graf, Markus; Mayer, Felix; et al. (2008)
    Advanced Materials
  • Growth of Epithelial Organoids in a Defined Hydrogel
    Item type: Journal Article
    Broguiere, Nicolas; Isenmann, Luca; Hirt, Christian; et al. (2018)
    Advanced Materials
    Epithelial organoids are simplified models of organs grown in vitro from embryonic and adult stem cells. They are widely used to study organ development and disease, and enable drug screening in patient‐derived primary tissues. Current protocols, however, rely on animal‐ and tumor‐derived basement membrane extract (BME) as a 3D scaffold, which limits possible applications in regenerative medicine. This prompted us to study how organoids interact with their matrix, and to develop a well‐defined hydrogel that supports organoid generation and growth. It is found that soft fibrin matrices provide suitable physical support, and that naturally occurring Arg‐Gly‐Asp (RGD) adhesion domains on the scaffold, as well as supplementation with laminin‐111, are key parameters required for robust organoid formation and expansion. The possibility to functionalize fibrin via factor XIII‐mediated anchoring also allows to covalently link fluorescent nanoparticles to the matrix for 3D traction force microscopy. These measurements suggest that the morphogenesis of budding intestinal organoids results from internal pressure combined with higher cell contractility in the regions containing differentiated cells compared to the regions containing stem cells. Since the fibrin/laminin matrix supports long‐term expansion of all tested murine and human epithelial organoids, this hydrogel can be widely used as a defined equivalent to BME.
Publications 1 - 10 of 269