Isabelle Mansuy


Last Name

Mansuy

First Name

Isabelle

ORCID

0000-0001-7785-5371

Organisational unit

03518 - Mansuy, Isabelle / Mansuy, Isabelle

Search Results

Publications 1 - 10 of 165
  • Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness
    Item type: Journal Article
    van Houtum, Lisanne A.E.M.; Baaré, William F.C.; Beckmann, Christian F.; et al. (2024)
    European Child & Adolescent Psychiatry
    Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission of risk for mental illness in one's children is insufficiently considered in clinical practice, nor is it sufficiently utilised into diagnostics and care for children of ill parents. This leads to delays in diagnosing young offspring and missed opportunities for protective actions and resilience strengthening. Prior twin, family, and adoption studies suggest that the aetiology of mental illness is governed by a complex interplay of genetic and environmental factors, potentially mediated by changes in epigenetic programming and brain development. However, how these factors ultimately materialise into mental disorders remains unclear. Here, we present the FAMILY consortium, an interdisciplinary, multimodal (e.g., (epi)genetics, neuroimaging, environment, behaviour), multilevel (e.g., individual-level, family-level), and multisite study funded by a European Union Horizon-Staying-Healthy-2021 grant. FAMILY focuses on understanding and prediction of intergenerational transmission of mental illness, using genetically informed causal inference, multimodal normative prediction, and animal modelling. Moreover, FAMILY applies methods from social sciences to map social and ethical consequences of risk prediction to prepare clinical practice for future implementation. FAMILY aims to deliver: (i) new discoveries clarifying the aetiology of mental illness and the process of resilience, thereby providing new targets for prevention and intervention studies; (ii) a risk prediction model within a normative modelling framework to predict who is at risk for developing mental illness; and (iii) insight into social and ethical issues related to risk prediction to inform clinical guidelines.
  • NanoTag is an improved method to map interactions between DNA and proteins not requiring IgG
    Item type: Journal Article
    Dimitriu, Maria A.; Arzate-Mejía, Rodrigo G.; Steg, Leonard C.; et al. (2025)
    Scientific Reports
    Genome-wide profiling of DNAprotein interactions in cells can provide important information about mechanisms of gene regulation. Most current methods for genome-wide profiling of DNA-bound proteins such as ChIP-seq and CUT&Tag use conventional IgG antibodies to bind the target protein(s). This limits their applicability to targets with available high affinity and specificity antibodies and prevents their use for other targets. Here we describe NanoTag, an IgG-free method derived from CUT&Tag to profile DNAprotein interactions. NanoTag is based on a fusion between an anti-GFP nanobody and Tn5 transposase that can map GFP-tagged proteins associated with chromatin in a fast, cost-effective and animal-free manner. We used NanoTag to indirectly profile the histone mark H3K4me3 genome-wide via its binding partner TATA box-binding protein-associated factor 3 (TAF3) and the transcription factors Nanog and CTCF in mouse embryonic stem cells (mESCs). NanoTag results show high inter-replicate reproducibility, high signal-to-noise ratio and strong correlation with CUT&Tag datasets, validating its accuracy and reliability. NanoTag provides a novel, flexible and cost-effective IgG-free method to generate high resolution DNA-binding profiles in cells and tissues.
  • Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus
    Item type: Journal Article
    Jouvenceau, Anne; Hédou, Gael; Potier, Brigitte; et al. (2006)
    European Journal of Neuroscience
  • Epigenetics of childhood trauma: Long term sequelae and potential for treatment
    Item type: Journal Article
    Thumfart, Kristina M.; Jawaid, Ali; Bright, Kristina; et al. (2022)
    Neuroscience & Biobehavioral Reviews
    Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk factors for neuropsychiatric diseases in adulthood. Recent advances in the field of epigenetics suggest that epigenetic factors such as DNA methylation and histone modifications, as well as regulatory processes involving non-coding RNA are associated with the long-term sequelae of CT. This narrative review summarizes current knowledge on the epigenetic basis of CT and describes studies in animal models and human subjects examining how the epigenome and transcriptome are modified by CT in the brain. It discusses psychological and pharmacological interventions that can counteract epigenetic changes induced by CT and the need to establish longitudinal assessment after CT for developing more effective diagnostics and treatment strategies based on epigenetic targets.
  • The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner
    Item type: Journal Article
    Woldemichael, Bisrat T.; Jawaid, Ali; Kremer, Eloïse A.; et al. (2016)
    Nature Communications
    Memory formation is a complex cognitive function regulated by coordinated synaptic and nuclear processes in neurons. In mammals, it is controlled by multiple molecular activators and suppressors, including the key signalling regulator, protein phosphatase 1 (PP1). Here, we show that memory control by PP1 involves the miR-183/96/182 cluster and its selective regulation during memory formation. Inhibiting nuclear PP1 in the mouse brain, or training on an object recognition task similarly increases miR-183/96/182 expression in the hippocampus. Mimicking this increase by miR-183/96/182 overexpression enhances object memory, while knocking-down endogenous miR-183/96/182 impairs it. This effect involves the modulation of several plasticity-related genes, with HDAC9 identified as an important functional target. Further, PP1 controls miR-183/96/182 in a transcription-independent manner through the processing of their precursors. These findings provide novel evidence for a role of miRNAs in memory formation and suggest the implication of PP1 in miRNAs processing in the adult brain.
  • Early life stress in fathers improves behavioural flexibility in their offspring
    Item type: Journal Article
    Gapp, Katharina; Soldado-Magraner, Saray; Alvarez-Sanchez, Maria; et al. (2014)
    Nature Communications
  • Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus
    Item type: Journal Article
    Papadopoulos, Theofilos; Eulenburg, Volker; Reddy-Alla, Suneel; et al. (2008)
    Molecular and Cellular Neuroscience
  • Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain
    Item type: Journal Article
    Hedou, Gael F.; Koshibu, Kyoko; Farinelli, Melissa; et al. (2008)
    The Journal of Neuroscience
  • Epigenetic inheritance in mammals
    Item type: Review Article
    Franklin, Tamara B.; Mansuy, Isabelle (2010)
    Neurobiology of Disease
  • Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 system
    Item type: Journal Article
    Michalon, Aubin; Koshibu, Kyoko; Baumgärtel, Karsten; et al. (2005)
    Genesis
Publications 1 - 10 of 165