Cecilia Valenzuela Agüí


Last Name

Valenzuela Agüí

First Name

Cecilia

ORCID

0000-0002-2774-4822

Organisational unit

09490 - Stadler, Tanja / Stadler, Tanja

Filters

2024 - 20252
Reset filters

Search Results

Publications 1 - 2 of 2
  • Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes)
    Item type: Journal Article
    Chan, Tatjana; Ginders, Julia; Kuhlmeier, Evelyn; et al. (2024)
    Viruses
    Many different animal species are susceptible to SARS-CoV-2, including a few Canidae (domestic dog and raccoon dog). So far, only experimental evidence is available concerning SARS-CoV-2 infections in red foxes (Vulpes vulpes). This is the first report of SARS-CoV-2 RNA detection in a sample from a red fox. The RT-qPCR-positive fox was zoo-kept together with another fox and two bears in the Swiss Canton of Zurich. Combined material from a conjunctival and nasal swab collected for canine distemper virus diagnostics tested positive for SARS-CoV-2 RNA with Ct values of 36.9 (E gene assay) and 35.7 (RdRp gene assay). The sample was analysed for SARS-CoV-2 within a research project testing residual routine diagnostic samples from different animal species submitted between spring 2020 and December 2022 to improve knowledge on SARS-CoV-2 infections within different animal species and investigate their potential role in a One Health context. Within this project, 246 samples from 153 different animals from Swiss zoos and other wild animal species all tested SARS-CoV-2 RT-qPCR and/or serologically negative so far, except for the reported fox. The source of SARS-CoV-2 in the fox is unknown. The fox disappeared within the naturally structured enclosure, and the cadaver was not found. No further control measures were undertaken.
  • Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages
    Item type: Journal Article
    Windels, Etthel; Valenzuela Agüí, Cecilia; De Jong, Bouke C.; et al. (2025)
    Epidemics
    Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological characterization by applying phylodynamic models to genomic data from different countries, representing the most abundant MTBC lineages. Our results suggest that all lineages are associated with similar durations and levels of infectiousness, resulting in similar reproductive numbers. However, L1 and L6 are associated with a delayed onset of infectiousness, leading to longer periods between subsequent transmission events. Together, our findings highlight the role of MTBC genetic diversity in tuberculosis disease progression and transmission.
Publications 1 - 2 of 2