Can High-Risk Fungicides be Used in Mixtures Without Selecting for Fungicide Resistance?
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Date
2014-04
Publication Type
Journal Article
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yes
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Abstract
Fungicide mixtures produced by the agrochemical industry often contain low-risk fungicides, to which fungal pathogens are fully sensitive, together with high-risk fungicides known to be prone to fungicide resistance. Can these mixtures provide adequate disease control while minimizing the risk for the development of resistance? We present a population dynamics model to address this question. We found that the fitness cost of resistance is a crucial parameter to determine the outcome of competition between the sensitive and resistant pathogen strains and to assess the usefulness of a mixture. If fitness costs are absent, then the use of the high-risk fungicide in a mixture selects for resistance and the fungicide eventually becomes nonfunctional. If there is a cost of resistance, then an optimal ratio of fungicides in the mixture can be found, at which selection for resistance is expected to vanish and the level of disease control can be optimized.
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published
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Journal / series
Volume
104 (4)
Pages / Article No.
324 - 331
Publisher
American Phytopathological Society
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Subject
Epidemiology; Plant disease; Mathematical model; Host-pathogen interaction; Fungicide resistance; Population dynamics
Organisational unit
03516 - McDonald, Bruce (emeritus) / McDonald, Bruce (emeritus)
03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian