Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
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Date
2018-01-16
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Journal Article
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Abstract
Acrolein is a highly reactive electrophile causing toxic effects, such as DNA and protein adduction, oxidative stress, endoplasmic reticulum stress, immune dysfunction, and membrane damage. This Opinion/Hypothesis provides an overview of endogenous and exogenous acrolein sources, acrolein’s mode of action, and its metabolic fate. Recent reports underpin the finding that gut microbial glycerol metabolism leading to the formation of reuterin is an additional source of endogenous acrolein. Reuterin is an antimicrobial multicomponent system consisting of 3-hydroxypropionaldehyde, its dimer and hydrate, and also acrolein. The major conclusion is that gut microbes can metabolize glycerol to reuterin and that this transformation occurs in vivo. Given the known toxicity of acrolein, the observation that acrolein is formed in the gut necessitates further investigations on functional relevance for gut microbiota and the host.
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published
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Volume
9 (1)
Pages / Article No.
Publisher
American Society for Microbiology
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Subject
endogenous acrolein; glycerol metabolism; gut microbiota; reuterin; toxicity
Organisational unit
03626 - Lacroix, Christophe (emeritus) / Lacroix, Christophe (emeritus)
03853 - Sturla, Shana / Sturla, Shana