Synergizing Algorithmic Design, Photoclick Chemistry and Multi-Material Volumetric Printing for Accelerating Complex Shape Engineering
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Date
2023-09-15
Publication Type
Journal Article
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yes
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Abstract
The field of biomedical design and manufacturing has been rapidly evolving, with implants and grafts featuring complex 3D design constraints and materials distributions. By combining a new coding-based design and modeling approach with high-throughput volumetric printing, a new approach is demonstrated to transform the way complex shapes are designed and fabricated for biomedical applications. Here, an algorithmic voxel-based approach is used that can rapidly generate a large design library of porous structures, auxetic meshes and cylinders, or perfusable constructs. By deploying finite cell modeling within the algorithmic design framework, large arrays of selected auxetic designs can be computationally modeled. Finally, the design schemes are used in conjunction with new approaches for multi-material volumetric printing based on thiol-ene photoclick chemistry to rapidly fabricate complex heterogeneous shapes. Collectively, the new design, modeling and fabrication techniques can be used toward a wide spectrum of products such as actuators, biomedical implants and grafts, or tissue and disease models.
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published
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Journal / series
Volume
10 (26)
Pages / Article No.
2300912
Publisher
Wiley-VCH
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Software
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Date created
Subject
algorithmic design; Auxetic; hydrogels; multi-material; volumetric printing
Organisational unit
03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
09830 - Qin, Xiao-Hua / Qin, Xiao-Hua
03565 - Müller, Ralph / Müller, Ralph
Notes
Funding
179012 - Skin biomechanics and mechanobiology for wound healing and tissue engineering (SNF)
188522 - Subtractive 3D Micro-Printing of Functional Osteocyte Networks as An In Vitro Model for Bone Organoids (SNF)
206501 - Human Organoid-on-Chip: A Novel Experimental Tool to Replace Animal Models of Rare Bone Disease (SNF)
188522 - Subtractive 3D Micro-Printing of Functional Osteocyte Networks as An In Vitro Model for Bone Organoids (SNF)
206501 - Human Organoid-on-Chip: A Novel Experimental Tool to Replace Animal Models of Rare Bone Disease (SNF)
Related publications and datasets
Is supplemented by: https://doi.org/10.3929/ethz-b-000583621