Local chemical stimulation of neurons using fluidfm technology combined with microelectrode arrays
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Author / Producer
Date
2015
Publication Type
Other Conference Item
ETH Bibliography
yes
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Abstract
It is still unclear how networks of neurons in the brain carry out individual functions such as information processing and storage. Better understanding these is a challenge of this century. We report the combination of microelectrode arrays to measure in vitro neuronal activity with the recently developed FluidFM technology acting as a force-controlled nanopipette to stimulate a neuron with the controlled release of a neurotransmitter. We show the possibility of localized release of glutamate on top of the target cell with precise control over force and spatial position therefore acting as an “artificial synapse”.
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published
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Book title
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)
Journal / series
Volume
Pages / Article No.
653 - 655
Publisher
Chemical and Biological Microsystems Society
Event
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2015)
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Methods
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Subject
Chemical stimulation; Neurotransmitter; Glutamate; Localized stimulation; Primary neurons; Electrophysiology; Microelectrode array; MEA; Atomic force microscope; AFM; FluidFM; Nanopipette
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Notes
Poster abstract. Poster presentation on October 27, 2015.