The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition
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Date
2023-02-01
Publication Type
Journal Article
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yes
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Abstract
Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3′UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM.
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published
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Journal / series
Volume
24 (3)
Pages / Article No.
2874
Publisher
MDPI
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Edition / version
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Date collected
Date created
Subject
Pleural mesothelioma; RNA editing; Epithelial-to-mesenchymal transition
Organisational unit
02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich