Fueling next-generation genome editing with DNA repair
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Author / Producer
Date
2023-12
Publication Type
Review Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
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Abstract
Genome editing technologies generate targeted DNA lesions and rely on cellular DNA repair pathways for resolution. Understanding the DNA repair mechanisms responsible for resolving the specific damage caused by gene editing tools can significantly advance their optimization and facilitate their broader application in research and therapeutic contexts. Here we explore the cellular processes involved in repairing base and prime editor-generated DNA lesions and strategies to leverage and manipulate DNA repair pathways for desired genomic changes.
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Publication status
published
External links
Editor
Book title
Journal / series
Volume
28
Pages / Article No.
100506
Publisher
Elsevier
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Base editor; Prime editor; DNA repair; Next-generation gene editing
Organisational unit
09635 - Corn, Jacob / Corn, Jacob
Notes
Funding
101070740 - FINE-TUNING T CELL NETWORKS OF EXHAUSTION BY SYNTHETIC SENSORS (SBFI)