Integrating multi-electrode arrays in microfluidic hanging-drop networks
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Date
2017
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Conference Paper
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yes
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Abstract
This work presents a highly versatile and scalable analytical platform for 3D microtissues. The device combines microfluidics for precise control of culture conditions with sensor technology for parallel and real-time monitoring of microtissue metabolism. The technology is based on an inverted, open microfluidic network. Interconnected hanging drops are formed underneath a patterned glass chip, which hosts the integrated microelectrode array. The electrodes can be individually functionalized and used as biosensors. The fabrication is simple, and the overall system can be expanded through the integration of larger numbers of hanging drops and more electrodes. The device can be used as a microfluidic platform for cultivation and continuous monitoring of 3D microtissues.
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published
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2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)
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91 - 94
Publisher
IEEE
Event
IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS 2017)
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Organisational unit
03684 - Hierlemann, Andreas / Hierlemann, Andreas
Notes
Funding
267351 - Seamless Integration of Neurons with CMOS Microelectronics (EC)
296257 - The Body-on-a-Chip (BoC) (EC)
142440 - The Body on a Chip - Human 3-D tissue analogues in microfluidic systems (SNF)
296257 - The Body-on-a-Chip (BoC) (EC)
142440 - The Body on a Chip - Human 3-D tissue analogues in microfluidic systems (SNF)