A parametric study on pulse duplicator design and valve hemodynamics
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Date
2024-09
Publication Type
Journal Article
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yes
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Abstract
Background: In vitro assessment is mandatory for artificial heart valve development. This study aims to investigate the effects of pulse duplicator features on valve responsiveness, conduct a sensitivity analysis across valve prosthesis types, and contribute on the development of versatile pulse duplicator systems able to perform reliable prosthetic aortic valve assessment under physiologic hemodynamic conditions.
Methods: A reference pulse duplicator was established based on literature. Further optimization process led to new designs that underwent a parametric study, also involving different aortic valve prostheses. These designs were evaluated on criteria such as mean pressure differential and pulse pressure (assessed from high-fidelity pressure measurements), valve opening and closing behavior, flow, and regurgitation. Finally, the resulting optimized setup was tested under five different hemodynamic settings simulating a range of physiologic and pathologic conditions.
Results: The results show that both, pulse duplicator design and valve type significantly influence aortic and ventricular pressure, flow, and valve kinematic response. The optimal design comprised key features such as a compliance chamber and restrictor for diastolic pressure maintenance and narrow pulse pressure. Additionally, an atrial reservoir was included to prevent atrial–aortic interference, and a bioprosthetic valve was used in mitral position to avoid delayed valve closing effects.
Conclusion: This study showed that individual pulse duplicator features can have a significant effect on valve's responsiveness. The optimized versatile pulse duplicator replicated physiologic and pathologic aortic valve hemodynamic conditions, serving as a reliable characterization tool for assessing and optimizing aortic valve performance.
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published
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Journal / series
Volume
48 (9)
Pages / Article No.
977 - 987
Publisher
Wiley-Blackwell
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Edition / version
Methods
Software
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Date collected
Date created
Subject
aortic valve; bioprosthetic valve; hemodynamic settings; mechanical valve; polymeric valve; pulse duplicator; valve characterization
Organisational unit
03507 - Ermanni, Paolo (emeritus) / Ermanni, Paolo (emeritus)
09667 - Falk, Volkmar / Falk, Volkmar