Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow
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Date
2017-10-25
Publication Type
Journal Article
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yes
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Abstract
Many microorganisms live in communities and
depend on metabolites secreted by fellow community
members for survival. Yet our knowledge of interspecies
metabolic dependencies is limited to few
communities with small number of exchanged metabolites,
and even less is known about cellular regulation
facilitating metabolic exchange. Here we show
how yeast enables growth of lactic acid bacteria
through endogenous, multi-component, crossfeeding
in a readily established community. In nitrogen-
rich environments, Saccharomyces cerevisiae
adjusts its metabolism by secreting a pool of metabolites,
especially amino acids, and thereby enables
survival of Lactobacillus plantarum and Lactococcus
lactis. Quantity of the available nitrogen sources and
the status of nitrogen catabolite repression pathways
jointly modulate this niche creation. We
demonstrate how nitrogen overflow by yeast benefits
L. plantarum in grape juice, and contributes to emergence
of mutualism with L. lactis in a medium with
lactose. Our results illustrate how metabolic decisions
of an individual species can benefit others.
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published
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Journal / series
Volume
5 (4)
Pages / Article No.
345 - 357000000
Publisher
Cell Press
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Organisational unit
03713 - Sauer, Uwe / Sauer, Uwe