Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms
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Date
2024-10-16
Publication Type
Journal Article
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yes
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Abstract
The initial delivery of small-scale magnetic devices such as microrobots is a key, but often overlooked, aspect for their use in clinical applications. The deployment of these devices within the dynamic environment of the human body presents significant challenges due to their dispersion caused by circulatory flows. Here, a method is introduced to effectively deliver a swarm of magnetic nanoparticles in fluidic flows. This approach integrates a magnetically navigated robotic microcatheter equipped with a reservoir for storing the magnetic nanoparticles. The microfluidic flow within the reservoir facilitates the injection of magnetic nanoparticles into the fluid stream, and a magnetic field gradient guides the swarm through the oscillatory flow to a target site. The microcatheter and reservoir are engineered to enable magnetic steering and injection of the magnetic nanoparticles. To demonstrate this approach, experiments are conducted utilizing a spinal cord phantom simulating intrathecal catheter delivery for applications in the central nervous system. These results demonstrate that the proposed microcatheter successfully concentrates nanoparticles near the desired location through the precise manipulation of magnetic field gradients, offering a promising solution for the controlled deployment of untethered magnetic micro-/nanodevices within the complex physiological circulatory systems of the human body.
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published
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Journal / series
Volume
11 (38)
Pages / Article No.
2404061
Publisher
Wiley-VCH
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Date collected
Date created
Subject
Magnetic catheter; magnetic control; magnetic nanoparticle swarm; magnetic nanoparticles; targeted delivery
Organisational unit
02205 - FIRST-Lab / FIRST Center for Micro- and Nanoscience
03627 - Nelson, Bradley J. (emeritus) / Nelson, Bradley J. (emeritus)
08705 - Gruppe Pané Vidal
Notes
Funding
771565C - Highly Integrated Nanoscale Robots for Targeted Delivery to the Central Nervous System (EC)
22-2 ETH-040 - ETH Grant application 22-2 ETH-040: Small-Scale Robotic Superstructures with Multifunctionality Reconfigurability, and Deployability (ETHZ)
198643 - Understanding Pollen Tube Growth Inspires the Design of Autonomous Soft Robots (SNF)
197017 - Flexible Electronics meets µ-Robotics: Route for Augmented Bio-Intelligent Medical Treatments (SNF)
952152 - MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutic agents in any vascular rEgion of the body (EC)
801464 - Ultra-versatile Structural PRINTing of amorphous and tuned crystalline matter on multiple substrates (EC)
22-2 ETH-040 - ETH Grant application 22-2 ETH-040: Small-Scale Robotic Superstructures with Multifunctionality Reconfigurability, and Deployability (ETHZ)
198643 - Understanding Pollen Tube Growth Inspires the Design of Autonomous Soft Robots (SNF)
197017 - Flexible Electronics meets µ-Robotics: Route for Augmented Bio-Intelligent Medical Treatments (SNF)
952152 - MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutic agents in any vascular rEgion of the body (EC)
801464 - Ultra-versatile Structural PRINTing of amorphous and tuned crystalline matter on multiple substrates (EC)