Detecting directional epistasis and dominance from cross-line analyses in alpine populations of Arabidopsis thaliana
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Date
2024-07
Publication Type
Journal Article
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yes
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Abstract
The contribution of non-additive genetic effects to the genetic architecture of fitness and to the evolutionary potential of populations has been a topic of theoretical and empirical interest for a long time. Yet, the empirical study of these effects in natural populations remains scarce, perhaps because measuring dominance and epistasis relies heavily on experimental line crosses. In this study, we explored the contribution of dominance and epistasis in natural alpine populations of Arabidopsis thaliana for 2 fitness traits, the dry biomass and the estimated number of siliques, measured in a greenhouse. We found that, on average, crosses between inbred lines of A. thaliana led to mid-parent heterosis for dry biomass but outbreeding depression for an estimated number of siliques. While heterosis for dry biomass was due to dominance, we found that outbreeding depression for an estimated number of siliques could be attributed to the breakdown of beneficial epistatic interactions. We simulated and discussed the implication of these results for the adaptive potential of the studied populations, as well as the use of line-cross analyses to detect non-additive genetic effects.
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published
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Journal / series
Volume
37 (7)
Pages / Article No.
839 - 847
Publisher
Oxford University Press
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Subject
non-additive genetic effects; dominance; epistasis; quantitative genetics; self-fertilization; Arabidopsis
Organisational unit
03706 - Widmer, Alexander / Widmer, Alexander