Quantitative measures of within-host viral genetic diversity
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Author / Producer
Date
2021-08
Publication Type
Review Article
ETH Bibliography
yes
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OPEN ACCESS
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Abstract
The genetic diversity of virus populations within their hosts is known to influence disease progression, treatment outcome, drug resistance, cell tropism, and transmission risk, and the study of dynamic changes of genetic heterogeneity can provide insights into the evolution of viruses. Several measures to quantify within-host genetic diversity capturing different aspects of diversity patterns in a sample or population are used, based on incidence, relative frequencies, pairwise distances, or phylogenetic trees. Here, we review and compare several of these measures.
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published
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Journal / series
Volume
49
Pages / Article No.
157 - 163
Publisher
Elsevier
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Edition / version
Methods
Software
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Date collected
Date created
Subject
Organisational unit
03790 - Beerenwinkel, Niko / Beerenwinkel, Niko
Notes
Funding
955974 - Understanding (harmful) virus-host interactions by linking virology and bioinformatics (EC)