Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams
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2023-09-01
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Journal Article
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Abstract
We report the cobalt-catalyzed aminocyclization of unsaturated N-acyl sulfonamides in the presence of oxygen to provide γ- and δ-lactam aldehydes. Use of an optically active cobalt catalyst resulted in the formation of enantiomerically enriched γ-and δ-lactam alcohols. The γ-lactam aldehydes and alcohols obtained were elaborated into useful building blocks.
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published
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25 (34)
Pages / Article No.
6380 - 6384
Publisher
American Chemical Society
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03511 - Carreira, Erick M. / Carreira, Erick M.
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833540 - Development of Stereoselective Olefin Functionalization Methods (EC)