Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of β-Octaarginine
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Date
2015
Publication Type
Journal Article
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yes
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Abstract
β³‐Octaarginine chains were attached to the functional groups NH and CO₂H of the antibacterial fluoroquinolones ciprofloxacin (→1) and enrofloxacin (→2), respectively, in order to find out whether the activity increases by attachment of the polycationic, cell‐penetrating peptide (CPP) moiety. For comparison, simple amides, 3–5, of the two antimicrobial compounds and β³‐octaarginine amide (βR₈) were included in the antibacterial susceptibility tests to clarify the impact of chemical modification on the microbiological activity of either scaffold (Table).
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published
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12 (2)
Pages / Article No.
179 - 193
Publisher
Wiley-VHCA
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03492 - Hilvert, Donald (emeritus) / Hilvert, Donald (emeritus)
Notes
Article first published online 10 February 2015.