Ectokinases as novel cancer markers and drug targets in cancer therapy
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Author / Producer
Date
2015-03
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
While small‐molecule kinase inhibitors became the most prominent anticancer drugs, novel combinatorial strategies need to be developed as the fight against cancer is not yet won. We review emerging literature showing that the release of several ectokinases is significantly upregulated in body fluids from cancer patients and that they leave behind their unique signatures on extracellular matrix (ECM) proteins. Our analysis of proteomic data reveals that fibronectin is heavily phosphorylated in cancer tissues particularly within its growth factor binding sites and on domains that regulate fibrillogenesis. We are thus making the case that cancer is not only a disease of cells but also of the ECM. Targeting extracellular kinases or the extracellular signatures they leave behind might thus create novel opportunities in cancer diagnosis as well as new avenues to interfere with cancer progression and malignancy.
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Publication status
published
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Editor
Book title
Journal / series
Volume
4 (3)
Pages / Article No.
404 - 414
Publisher
Wiley
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Cancer marker; Drug design; Ectokinases; Exokinases; Extracellular matrix; Extracellular phosphorylation; Extracellular protein kinase; Personalized medicine
Organisational unit
03640 - Vogel, Viola (emeritus) / Vogel, Viola (emeritus)