A microfluidic hanging-drop system to study the secretion dynamics of single pancreatic iIslet microtissues
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Date
2017
Publication Type
Other Conference Item
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yes
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Abstract
We present an analytical microfluidic system that employs uniform re-aggregated islets to study glucosestimulated insulin secretion (GSIS). The high sampling rate enables to resolve the physiologically characteristic biphasic and pulsatile insulin release from healthy β-cells of the pancreatic islets. Loss of the first phase, reduction in the second phase and impairment of the oscillatory pattern of insulin secretion are characteristic features of type 2 diabetes. Therefore, investigation of the dynamics of insulin secretion is important to understand the pathophysiology of diabetes as well as to study pharmacokinetics and the mechanisms of anti-diabetic medication.
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published
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Editor
Book title
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Journal / series
Volume
Pages / Article No.
814 - 815
Publisher
Chemical and Biological Microsystems Society
Event
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2017)
Edition / version
Methods
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Date collected
Date created
Subject
Microfluidics; Hanging drop; 3D microtissue; GSIS; Pancreatic islets
Organisational unit
03684 - Hierlemann, Andreas / Hierlemann, Andreas
Notes
Poster abstract. Poster presentation on October 26, 2017.
Funding
166329 - “Infected Body-on-a-Chip”: Microfluidic Impedance Platform for Antischistosomal Drug Discovery (SNF)