Reconfigurable Magnetic Microswarm for Thrombolysis under Ultrasound Imaging
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Date
2020
Publication Type
Conference Paper
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yes
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Abstract
We propose thrombolysis using a magnetic nanoparticle microswarm with tissue plasminogen activator (tPA) under ultrasound imaging. The microswarm is generated in blood using an oscillating magnetic field and can be navigated with locomotion along both the long and short axis. By modulating the input field, the aspect ratio of the microswarm can be reversibly tuned, showing the ability to adapt to different confined environments. Simulation results indicate that both in-plane and out-of-plane fluid convection are induced around the microswarm, which can be further enhanced by tuning the aspect ratio of the microswarm. Under ultrasound imaging, the microswarm is navigated in a microchannel towards a blood clot and deformed to obtain optimal lysis. Experimental results show that the lysis rate reaches -0.1725 ± 0.0612 mm 3 /min in the 37°C blood environment under the influence of the microswarm-induced fluid convection and tPA. The lysis rate is enhanced 2.5-fold compared to that without the microswarm (-0.0681 ± 0.0263 mm 3 /min). Our method provides a new strategy to increase the efficiency of thrombolysis by applying microswarm-induced fluid convection, indicating that swarming micro/nanorobots have the potential to act as effective tools towards targeted therapy. © 2020 IEEE.
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Publication status
published
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Book title
2020 IEEE International Conference on Robotics and Automation (ICRA)
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Pages / Article No.
10285 - 10291
Publisher
IEEE
Event
IEEE International Conference on Robotics and Automation (ICRA 2020)
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Subject
Micro/nanorobot; Magnetic control; Collective behavior; Thrombolysis; Ultrasound imaging
Organisational unit
03627 - Nelson, Bradley J. / Nelson, Bradley J.
Notes
Due to the Coronavirus (COVID-19) the conference was conducted virtually.