A consensus guide to preclinical indirect calorimetry experiments
METADATA ONLY
Loading...
Author / Producer
Date
2025-09
Publication Type
Review Article
ETH Bibliography
yes
METADATA ONLY
Data
Rights / License
Abstract
Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data repository built on shared standards. This overdue initiative stands to markedly improve the accuracy and depth of efforts to interrogate mammalian metabolism. Data sharing according to established best practices will also accelerate the translation of basic findings into clinical applications for metabolic diseases afflicting global populations.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
7 (9)
Pages / Article No.
1765 - 1780
Publisher
Nature
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
Notes
Authors on behalf of The International Indirect Calorimetry Consensus Committee (IICCC)