The inflammatory response of lymphatic endothelium
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Author / Producer
Date
2014-04
Publication Type
Journal Article
ETH Bibliography
yes
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OPEN ACCESS
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Abstract
Lymphatic vessels have traditionally been regarded as a rather inert drainage system, which just passively transports fluids, leukocytes and antigen. However, it is becoming increasingly clear that the lymphatic vasculature is highly dynamic and plays a much more active role in inflammatory and immune processes. Tissue inflammation induces a rapid, stimulus-specific upregulation of chemokines and adhesion molecules in lymphatic endothelial cells and a proliferative expansion of the lymphatic network in the inflamed tissue and in draining lymph nodes. Moreover, increasing evidence suggests that inflammation-induced changes in the lymphatic vasculature have a profound impact on the course of inflammatory and immune responses, by modulating fluid drainage, leukocyte migration or the removal of inflammatory mediators from tissues. In this review we will summarize and discuss current knowledge of the inflammatory response of lymphatic endothelium and of inflammation-induced lymphangiogenesis and the current perspective on the overall functional significance of these processes.
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Publication status
published
External links
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Book title
Journal / series
Volume
17 (2)
Pages / Article No.
383 - 393
Publisher
Springer
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Inflammation; Lymphatic endothelial cells; Lyphangiogenesis; Leukocyte migration; Chemokines; Drainage
Organisational unit
03816 - Halin Winter, Cornelia / Halin Winter, Cornelia
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Funding
138330 - Elucidating the impact of inflammation on lymphatic vessel function and on the induction of adaptive immunity (SNF)