Theory for a non-invasive diagnostic biomarker for craniospinal diseases
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Date
2023
Publication Type
Journal Article
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yes
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Abstract
Monitoring intracranial pressure (ICP) and craniospinal compliance (CC) is frequently required in the treatment of patients suffering from craniospinal diseases. However, current approaches are invasive and cannot provide continuous monitoring of CC. Dynamic exchange of blood and cerebrospinal fluid (CSF) between cranial and spinal compartments due to cardiac action transiently modulates the geometry and dielectric properties of the brain. The resulting impedance changes can be measured and might be usable as a non-invasive CC surrogate. A numerically robust and computationally efficient approach based on the reciprocity theorem was developed to compute dynamic impedance changes resulting from small geometry and material property changes. The approach was successfully verified against semi-analytical benchmarks, before being combined with experimental brain pulsation data to study the information content of the impedance variation. The results indicate that the measurable signal is dominated by the pulsatile displacement of the cortical brain surface, with minor contributions from the ventricular surfaces and from changes in brain perfusion. Different electrode setups result in complementary information. The information content from the investigated three electrode pairs was employed to successfully infer subject-specific brain pulsation and motion features. This suggests that non-invasive CC surrogates based on impedance monitoring could be established.
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published
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Journal / series
Volume
37
Pages / Article No.
103280
Publisher
Elsevier
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Date collected
Date created
Subject
Intracranial pressure; Craniospinal compliance; Non-invasive diagnostics; Craniospinal disease screening; Continuous monitoring; Computational electrostatics
Organisational unit
02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering
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