Autoimmunity and SARS-CoV-2 infection: Unraveling the link in neurological disorders
OPEN ACCESS
Loading...
Author / Producer
Date
2022-10
Publication Type
Review Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Abstract
According to the World Health Organization, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more than 400 million people and caused over 5 million deaths globally. The infection is associated with a wide spectrum of clinical manifestations, ranging from no signs of illness to severe pathological complications that go beyond the typical respiratory symptoms. On this note, new-onset neurological and neuropsychiatric syndromes have been increasingly reported in a large fraction of COVID-19 patients, thus potentially representing a significant public health threat. Although the underlying pathophysiological mechanisms remain elusive, a growing body of evidence suggests that SARS-CoV-2 infection may trigger an autoimmune response, which could potentially contribute to the establishment and/or exacerbation of neurological disorders in COVID-19 patients. Shedding light on this aspect is urgently needed for the development of effective therapeutic intervention. This review highlights the current knowledge of the immune responses occurring in Neuro-COVID patients and discusses potential immune-mediated mechanisms by which SARS-CoV-2 infection may trigger neurological complications.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
52 (10)
Pages / Article No.
1561 - 1571
Publisher
Wiley-VCH
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
autoimmunity; COVID-19; neuro-COVID; neuroimmunology; SARS-CoV-2
Organisational unit
02520 - Institut für Mikrobiologie / Institute of Microbiology
Notes
Funding
185742 - Isolation and characterization of conventional and unconventional autoreactive T cells in Guillain-Barré syndrome (SNF)