A guide to designing germline-dependent epigenetic inheritance experiments in mammals
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Author / Producer
Date
2017-02
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
Recent work has demonstrated that environmental factors experienced by parents can affect their offspring across multiple generations, and that such transgenerational transmission can depend on the germline. Causal evidence for the involvement of germ cells is rare, however, and the underlying molecular mechanisms remain poorly understood. Further, studies often employ varying methods in experimental design and data interpretation. We provide a critical analysis of these issues and suggest possible solutions and guidelines for improving study design and generating reproducible and high-quality data.
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Publication status
published
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Editor
Book title
Journal / series
Volume
14 (3)
Pages / Article No.
243 - 249
Publisher
Nature
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Epigenetics; Epigenomics
Organisational unit
03518 - Mansuy, Isabelle / Mansuy, Isabelle
09499 - Bohacek, Johannes / Bohacek, Johannes
02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology