Hitting the sweet spot: glycans as targets of fungal defense effector proteins
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Date
2015-05
Publication Type
Review Article
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yes
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Abstract
Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparatively low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators.
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published
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Journal / series
Volume
20 (5)
Pages / Article No.
8144 - 8167
Publisher
MDPI
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Software
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Subject
Antibiosis; Resistance; Fungi; Nematodes; Bacteria; Lectin; Defensin; Toxin; Glycolipid; Glycoprotein
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Notes
Funding
149512 - Regulation, physiologische Bedeutung und Spezifität der chemischen Abwehr von multizellulären Pilzen gegen Fressfeinde (SNF)