Laminar Flow-Based Fiber Fabrication and Encoding via Two-Photon Lithography
METADATA ONLY
Loading...
Author / Producer
Date
2020-12-02
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
In recent years, flow photolithography (FL) has emerged as a powerful synthetic tool for the creation of barcoded microparticles with complex morphologies and chemical compositions which have been shown to be useful in a range of multiplexed bioassay applications. More specifically, FL has been highly successful in producing micron-sized, encoded particles of bespoke shape, size, and color. That said, to date, FL has been restricted to generating barcoded microparticles and has lacked the ability to produce hybrid fibers which are structurally and spectrally encoded. To this end, we herein present a method that combines a continuous flow microfluidic system with two-photon polymerization (2PP) to fabricate microscale-encoded fibers and Janus strips in a high-throughput manner. Specifically, two co-flow liquid streams containing a monomer and initiator are introduced through a Y-shape channel to form a stable interface in the center of a microfluidic channel. The flow containing the (fluorescently labeled) monomer is then patterned by scanning the voxel of the 2PP laser across the interface to selectively polymerize different regions of the forming fiber/particle. Such a process allows for rapid spectral encoding at the single fiber level, with the resulting structurally coded fibers having obvious application in the fields of security identification and anticounterfeiting.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
12 (48)
Pages / Article No.
54068 - 54074
Publisher
American Chemical Society
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Microfluidics; Laminar flow; Two-photon polymerization; Hybrid fiber; Barcoding
Organisational unit
03914 - deMello, Andrew / deMello, Andrew
03887 - Wang, Jing / Wang, Jing
08821 - Fischer, Peter (Tit.-Prof.)