Assembly and nuclear export of pre-ribosomal particles in budding yeast
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Date
2014-08
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
The ribosome is responsible for the final step of decoding genetic information into proteins. Therefore, correct assembly of ribosomes is a fundamental task for all living cells. In eukaryotes, the construction of the ribosome which begins in the nucleolus requires coordinated efforts of >350 specialized factors that associate with pre-ribosomal particles at distinct stages to perform specific assembly steps. On their way through the nucleus, diverse energy-consuming enzymes are thought to release assembly factors from maturing pre-ribosomal particles after accomplishing their task(s). Subsequently, recruitment of export factors prepares pre-ribosomal particles for transport through nuclear pore complexes. Pre-ribosomes are exported into the cytoplasm in a functionally inactive state, where they undergo final maturation before initiating translation. Accumulating evidence indicates a tight coupling between nuclear export, cytoplasmic maturation, and final proofreading of the ribosome. In this review, we summarize our current understanding of nuclear export of pre-ribosomal subunits and cytoplasmic maturation steps that render pre-ribosomal subunits translation-competent.
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Publication status
published
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Book title
Journal / series
Volume
123 (4)
Pages / Article No.
327 - 344
Publisher
Springer
Event
Edition / version
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Software
Geographic location
Date collected
Date created
Subject
Nuclear export; Assembly Factor; Nuclear pore complex; Nuclear Export Signal; Ribosome assembly
Organisational unit
03884 - Panse, Vikram G. (SNF-Professur) (ehem.)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Funding
260676 - Dissecting the biogenesis of eukaryotic ribosomal subunits (EC)