BTB proteins as henchmen of Cul3-based ubiquitin ligases
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Date
2003-11-01
Publication Type
Other Journal Item
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yes
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Abstract
The choice of ubiquitination substrates of Cul1- and Cul2-based E3 ubiquitin protein ligase complexes is dictated by the identity of their substrate-specific adaptors, known as F-box and BC-box proteins, respectively. Recent work suggests that members of the large family of BTB-domain proteins define a new class of substrate-specific adaptors of Cul3-based E3 complexes. This finding places many signalling pathways in which BTB-domain proteins participate under direct control of the ubiquitination pathway.
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published
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Volume
5 (11)
Pages / Article No.
950 - 951
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Software
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Organisational unit
03630 - Krek, Wilhelm (ehemalig) / Krek, Wilhelm (former)
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