Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion
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Date
2021-03-04
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Other Journal Item
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yes
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Abstract
Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell, Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation. © 2021 Elsevier
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published
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Volume
28 (3)
Pages / Article No.
359 - 361
Publisher
Cell Press
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03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian