TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3(neg)CD127(+) Immune Cells in Spleen and Mucosa
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2010
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Journal Article
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yes
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Abstract
In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3negCD127+ immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3negCD127+ cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.
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published
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185 (2)
Pages / Article No.
1177 - 1185
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AAI
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03589 - Hardt, Wolf-Dietrich / Hardt, Wolf-Dietrich
Notes
Published online June 21 2010.