Sucar Coating the Envelope: Glycoconjucates for Microbe-Host Crosstalk
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Date
2016-11
Publication Type
Journal Article
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yes
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Abstract
Tremendous progress has been made on mapping the mainly bacterial members of the human intestinal microbiota. Knowledge on what is out there, or rather what is inside, needs to be complemented with insight on how these bacteria interact with their biotic environment. Bacterial glycoconjugates, that is, the collection of all glycan-modified molecules, are ideal modulators of such interactions. Their enormous versatility and diversity results in a species-specific glycan barcode, providing a range of ligands for host interaction. Recent reports on the functional importance of glycosylation of important bacterial ligands in beneficial and pathogenic species underpin this. Glycoconjugates, and glycoproteins in particular, are an underappreciated, potentially crucial, factor in understanding bacteria–host interactions of old friends and foes.
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published
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Journal / series
Volume
24 (11)
Pages / Article No.
853 - 861
Publisher
Elsevier
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Subject
Microbiota; Glycoconjugates; Glycoproteins; Pili; Microbiota-host interactions; Glycobiology