Geometric effects position renal vesicles during kidney development
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Date
2023-12-26
Publication Type
Journal Article
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yes
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Abstract
During kidney development, reciprocal signaling between the epithelium and the mesenchyme coordinates nephrogenesis with branching morphogenesis of the collecting ducts. The mechanism that positions the renal vesicles, and thus the nephrons, relative to the branching ureteric buds has remained elusive. By combining computational modeling and experiments, we show that geometric effects concentrate the key regulator, WNT9b, at the junctions between parent and daughter branches where renal vesicles emerge, even when uniformly expressed in the ureteric epithelium. This curvature effect might be a general paradigm to create non-uniform signaling in development.
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published
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Journal / series
Volume
42 (12)
Pages / Article No.
113526
Publisher
Cell Press
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Subject
renal development; lightsheet microscopy; computational modeling
Organisational unit
03791 - Iber, Dagmar / Iber, Dagmar
Notes
Funding
170930 - A 3D Cell-Based Simulation Framework for Morphogenetic Problems (SNF)
Related publications and datasets
Is new version of: https://doi.org/10.3929/ethz-b-000590936