Validation of breath biomarkers for obstructive sleep apnea
OPEN ACCESS
Loading...
Author / Producer
Date
2021-09
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Rights / License
Abstract
Background and objectives
Obstructive sleep apnea (OSA) is an underdiagnosed respiratory disease with negative metabolic and cardiovascular effects. The current gold standard for diagnosing OSA is in-hospital polysomnography, a time-consuming and costly procedure, often inconvenient for the patient. Recent studies revealed evidence for the potential of breath analysis for the diagnosis of OSA based on a disease-specific metabolic pattern. However, none of these findings were validated in a larger and broader cohort, an essential step for its application in clinics.
Methods
In the present study, we validated a panel of breath biomarkers in a cohort of patients with possible OSA (N = 149). These markers were previously identified in our group by secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS).
Results
Here, we could confirm significant differences between metabolic patterns in exhaled breath from OSA patients compared to control subjects without OSA as well as the association of breath biomarker levels with disease severity. Our prediction of the diagnosis for the patients from this completely independent validation study using a classification model trained on the data from the previous study resulted in an area under the receiver operating characteristic curve of 0.66, which is comparable to questionnaire-based OSA screenings.
Conclusions
Thus, our results suggest that breath analysis by SESI-HRMS might be useful to screen for OSA as an objective measure. However, its true predictive power should be tested in combination with OSA screening questionnaires.
Clinical trial
“Mass Spectral Fingerprinting in Obstructive Sleep Apnoea”, NCT02810158, www.ClinicalTrials.gov.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
85
Pages / Article No.
75 - 86
Publisher
Elsevier
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Obstructive sleep apnea; Biomarkers; Validation study; Breath analysis; Metabolomics; Secondary electrospray ionization mass spectrometry
Organisational unit
03430 - Zenobi, Renato / Zenobi, Renato
Notes
Funding
Related publications and datasets
Is supplemented by: