Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
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Author / Producer
Date
2025-06
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
Circulating tumor cell (CTC) clusters are highly efficient metastatic seeds in various cancers. Yet, their genetic heterogeneity and clonal architecture is poorly characterized. Using whole-exome sequencing coupled with phylogenetic inference from CTC clusters of patients with breast and prostate cancer, as well as mouse cancer models alongside barcode-mediated clonal tracking in vivo, we demonstrate oligoclonal composition of individual CTC clusters. These results improve our understanding of metastasis-relevant clonal dynamics.
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published
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Editor
Book title
Journal / series
Nature Genetics
Volume
57 (6)
Pages / Article No.
1357 - 1361
Publisher
Nature
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
09736 - Aceto, Nicola / Aceto, Nicola
03790 - Beerenwinkel, Niko / Beerenwinkel, Niko
Notes
Funding
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