Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo
METADATA ONLY
Loading...
Author / Producer
Date
2018-10-07
Publication Type
Journal Article
ETH Bibliography
no
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
Hemorrhage or uncontrolled bleeding can arise either due to a medical condition or from a traumatic injury and are typically controlled with the application of a hemostatic agent. Hemostatic agents are currently derived from animal or human products, which carry risks of blood borne infections and immune dysregulation. Therefore, the need exists for novel biomedical therapies not derived from animal or human products to achieve hemostasis. Accordingly, we created an interdigitated microelectronic bandage that applies low voltage electrical stimulation to an injury site, resulting in faster clot formation without excessive heating, accelerated fibrin formation, and hemostasis overall. Our interdigitated microelectronic bandage found fibrin formed 1.5× faster in vitro. In vivo, total cessation of bleeding was 2.5× faster, resulting in 2× less blood loss. Electricity has been used in medical applications such as defibrillation, cauterization, and electrosurgery, but scant research has focused on hemostasis. Here we report a novel surface treatment using an interdigitated microelectronic device that creates rapid hemostasis in both in vitro and in vivo bleeding models with low applied voltages, representing a new and novel class of hemostatic agents that are electrically-based.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
18 (19)
Pages / Article No.
2985 - 2993
Publisher
Royal Society of Chemistry
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
09757 - Wang, Hua / Wang, Hua