LED-based optoacoustic tomography of mice
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Date
2025-04
Publication Type
Journal Article
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yes
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Abstract
Significance: Optoacoustic tomography systems commonly employ bulky and expensive solid-state laser sources readily capable of generating dozens of millijoules of optical energy per pulse. Light-emitting diodes (LEDs) may offer a significantly more affordable and compact solution with excellent pulse-to-pulse stability. Yet, the optical design must optimize the energy density delivered to the target, given the relatively low per-pulse energy output of LEDs. Aim: We exploit a full-view LED-based optoacoustic tomography (FLOAT) configuration for in vivo imaging of mice. Approach: The system features panoramic light illumination delivering 0.48 mJ of total per-pulse energy with an array of 160 LEDs stacked into a cylindrically focused circular ultrasound array transducer. Results: We characterize the imaging performance of the FLOAT system in tissue-mimicking phantoms, subsequently demonstrating its ability for in vivo cross-sectional mouse imaging. Conclusions: It is anticipated that the compact, low-cost FLOAT imaging system will open up new venues in resource-limited settings for studying large-scale biodynamics such as pharmacokinetics and biodistribution of molecular agents and drugs on a whole-body level.
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published
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Journal / series
Volume
30 (4)
Pages / Article No.
40501
Publisher
SPIE
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Date collected
Date created
Subject
light-emitting diode; whole-body imaging; optoacoustic/photoacoustic tomography; affordable light sources
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Funding
ETH-C-01 21-2 - ListenToLight: a Smart Compact Optoacoustic System (ETHZ)