Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery
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Author / Producer
Date
2020-05-11
Publication Type
Review Article
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yes
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Abstract
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.
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Publication status
published
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Book title
Journal / series
Volume
59 (20)
Pages / Article No.
7669 - 7677
Publisher
Wiley-VCH
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Edition / version
Methods
Software
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Date collected
Date created
Subject
Bioorthogonal labeling; Biosensors; Drug delivery; Fluorescent probes; Genetically encoded tags
Organisational unit
Notes
Funding
165551 - Development of Intracellular Photoactivatable Probes (SNF)